侵袭伪足：胰腺癌治疗的一个潜在靶点。

Invadopodia: A potential target for pancreatic cancer therapy.

机构信息

Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

出版信息

Crit Rev Oncol Hematol. 2021 Mar;159:103236. doi: 10.1016/j.critrevonc.2021.103236. Epub 2021 Jan 20.

DOI:10.1016/j.critrevonc.2021.103236

PMID:33482351

Abstract

Dissemination of cancer cells is an intricate multistep process that represents the most deadly aspect of cancer. Cancer cells form F-actin-rich protrusions known as invadopodia to invade surrounding tissues, blood vessels and lymphatics. A number of studies have demonstrated the significant roles of invadopodia in cancer. Therefore, the specific cells and molecules involved in invadopodia activity can provide as therapeutic targets. In this review, we included a thorough overview of studies in invadopodia and discussed their functions in cancer metastasis. We then presented the specific cells and molecules involved in invadopodia activity in pancreatic cancer and analyzed their suitability to be effective therapeutic targets. Currently, drugs targeting invadopodia and relevant clinical trials are negligible. Here, we highlighted the significance of potential drugs and discussed future obstacles in implementing clinical trials. This review presents a new perspective on invadopodia-induced pancreatic cancer metastasis and may prosper the development of targeted therapeutics against pancreatic cancer.

摘要

癌细胞的扩散是一个复杂的多步骤过程，是癌症最致命的表现。癌细胞形成富含 F-肌动蛋白的突起，称为侵袭伪足，以侵袭周围组织、血管和淋巴管。许多研究已经证明了侵袭伪足在癌症中的重要作用。因此，参与侵袭伪足活动的特定细胞和分子可以作为治疗靶点。在这篇综述中，我们对侵袭伪足的研究进行了全面概述，并讨论了它们在癌症转移中的功能。然后，我们介绍了参与胰腺癌侵袭伪足活动的特定细胞和分子，并分析了它们作为有效治疗靶点的适宜性。目前，针对侵袭伪足的药物和相关临床试验微乎其微。在这里，我们强调了潜在药物的重要性，并讨论了实施临床试验的未来障碍。本综述为侵袭伪足诱导的胰腺癌转移提供了新的视角，并可能促进针对胰腺癌的靶向治疗药物的发展。