Department of Internal Medicine, Kaiser Permanente Fontana Medical Center, Fontana, CA.
Department of Pathology, Kaiser Permanente LAMC, Los Angeles, CA.
Perm J. 2020 Dec;24:1-3. doi: 10.7812/TPP/20.029.
Peripheral nerve sheath tumors, known as perineuriomas, are typically found on the trunk and extremities. They are less commonly described in the gastrointestinal tract (GI), and extremely rarely are described in the stomach.
We present a case of a 2-cm gastric perineurioma in a 42-year-old patient with nonspecific GI complaints of chronic dyspepsia and epigastric discomfort. Esophagogastroduodenoscopy, followed by endoscopic ultrasound, revealed a 2-cm umbilicated lesion in the stomach, which was subsequently removed with endoscopic submucosal dissection and sent for pathology. Immunohistochemical staining revealed a rare entity known as a gastric perineurioma.
Since the first case of gastric perineurioma was first described in 2004, there have only been 4 reported cases in the English literature. This case highlights the crucial interdisciplinary multidisciplinary effort between pathologists and GI specialists required to reach this diagnosis and showcases endoscopic diagnosis using endoscopic dissection, which allows for complete lesion resection and complete resolution of the patient's symptoms.
外周神经鞘肿瘤，又称神经鞘瘤，通常发生在躯干和四肢。它们在胃肠道（GI）中较少被描述，在胃中则极为罕见。
我们报告了一例 42 岁患者的 2 厘米胃神经鞘瘤，该患者有非特异性 GI 症状，包括慢性消化不良和上腹部不适。食管胃十二指肠镜检查，随后进行内镜超声检查，显示胃中有一个 2 厘米的脐状病变，随后通过内镜黏膜下剥离术切除，并进行病理检查。免疫组织化学染色显示一种罕见的实体，即胃神经鞘瘤。
自 2004 年首例胃神经鞘瘤被描述以来，英文文献中仅报道了 4 例。本病例强调了病理学家和 GI 专家之间需要进行关键的跨学科多学科努力，以做出这一诊断，并展示了使用内镜下剥离术进行内镜诊断的优势，这种方法可以实现完全切除病变并完全缓解患者的症状。
