Macarenco Ricardo S, Ellinger Fred, Oliveira Andre M
CIPAX-Medicina Diagnostica, Sao Jose dos Campos, SP, Brazil.
Arch Pathol Lab Med. 2007 Apr;131(4):625-36. doi: 10.5858/2007-131-625-PADAUP.
Perineuriomas are benign peripheral nerve sheath neoplasms composed of perineurial cells with characteristic immunohistochemical and ultrastructural features. They have been traditionally classified into two main types according to their location--intraneural and extraneural--and overlap histologically with many other tumors, which may be diagnostically challenging to general surgical pathologists.
To review the clinical, morphologic, immunohistochemical, ultrastructural, cytogenetic, and molecular genetic aspects of perineurioma, as well as to discuss its clinicopathologic variants and differential diagnosis.
English-language literature published between 1966 and 2005 was reviewed.
The correct identification of perineuriomas is important to avoid unnecessary overtreatment. The histologic diagnosis should be confirmed through immunohistochemical studies (including epithelial membrane antigen, S100 protein, and more recently described antibodies such as claudin-1 and GLUT1) or electron microscopy. Cytogenetic and molecular genetic studies are still of limited value for the diagnosis of perineuriomas but may play a fundamental role in excluding important differential diagnoses and also in helping elucidate the biology of these poorly known neoplasms.
神经束膜瘤是由具有特征性免疫组化和超微结构特征的神经束膜细胞组成的良性周围神经鞘瘤。传统上，它们根据位置分为两种主要类型——神经内型和神经外型——并且在组织学上与许多其他肿瘤重叠，这对普通外科病理学家来说可能具有诊断挑战性。
回顾神经束膜瘤的临床、形态学、免疫组化、超微结构、细胞遗传学和分子遗传学方面，以及讨论其临床病理变异和鉴别诊断。
回顾了1966年至2005年间发表的英文文献。
正确识别神经束膜瘤对于避免不必要的过度治疗很重要。组织学诊断应通过免疫组化研究（包括上皮膜抗原、S100蛋白以及最近描述的抗体如claudin-1和GLUT1）或电子显微镜检查来证实。细胞遗传学和分子遗传学研究对神经束膜瘤的诊断价值仍然有限，但在排除重要的鉴别诊断以及帮助阐明这些鲜为人知的肿瘤的生物学特性方面可能发挥重要作用。
