Ho Yuen B
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada.
Am J Obstet Gynecol. 1988 Mar;158(3 Pt 1):583-6. doi: 10.1016/0002-9378(88)90032-4.
The concentrations of prolactin in the milk of nine postpartum lactating mothers were determined by radioimmunoassay between days 3 to 280 of the puerperium (n = 324 samples). In addition, prolactin in milk was also determined at the beginning and the end of suckling in three of the same women, who provided 21 paired samples of foremilk and hindmilk between days 7 and 88 of the puerperium. Prolactin content was highest at 43.1 +/- 4 ng/ml (mean +/- SEM) in the early transition milk immediately after the colostrum phase during the first postpartum week, decreasing to 11.0 +/- 1.4 ng/ml in the mature milk (p less than 0.01) when weaning occurred in those mothers who breastfed for up to 40 weeks post partum. During suckling, the foremilk contained significantly more prolactin as compared with the hindmilk (29.5 +/- 2.7 versus 21.0 +/- 3.2 ng/ml; p less than 0.01). These findings, taken together with the known biologic potency of prolactin in breast milk, the osmoregulatory influence of the hormone in mammary and intestinal function, and its absorption by the newborn experimental animal, suggest that the presence of prolactin in milk may play some role in both lactation and the intestinal absorptive function of the suckling newborn.
采用放射免疫分析法测定了9名产后哺乳期母亲在产褥期第3天至280天的乳汁中催乳素浓度（共324份样本）。此外，还对其中3名女性在哺乳开始时和结束时乳汁中的催乳素进行了测定，她们在产褥期第7天至88天提供了21对初乳和后奶样本。产后第一周初乳期过后的早期过渡乳中催乳素含量最高，为43.1±4 ng/ml（平均值±标准误），在产后哺乳长达40周的母亲断奶时，成熟乳中的催乳素含量降至11.0±1.4 ng/ml（p<0.01）。哺乳期间，初乳中的催乳素含量明显高于后奶（29.5±2.7 ng/ml对21.0±3.2 ng/ml；p<0.01）。这些发现，结合已知的母乳中催乳素的生物学活性、该激素对乳腺和肠道功能的渗透调节作用以及新生实验动物对其的吸收情况，表明乳汁中催乳素的存在可能在哺乳和哺乳新生儿的肠道吸收功能中都发挥一定作用。
