Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
School of Neurobiology, Biochemistry and Biophysics, the George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Cell Death Dis. 2021 Jan 22;12(1):120. doi: 10.1038/s41419-020-03361-5.
Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease.
泛素化和去泛素化在蛋白质动态平衡（蛋白稳态）中起着关键作用。蛋白稳态塑造了人类大脑中的蛋白质组景观，其功能障碍与神经发育和神经退行性疾病有关。在这里，我们讨论了去泛素化酶在神经元功能和存活中的新作用。我们提供了一个关于去泛素化酶在神经元健康和疾病中的遗传学、生理学、结构和功能的最新视角。
