Paediatric and Community Dentistry, Minia University, Minya, Egypt.
Dental Biomaterials, Faculty of Dentistry, Minia University, Minya, Egypt.
Clin Oral Investig. 2021 Aug;25(8):4915-4925. doi: 10.1007/s00784-021-03800-3. Epub 2021 Jan 22.
The current study was carried out to (1) evaluate premixed bioceramic (BC) and mineral trioxide aggregate (MTA) sealing properties in a laboratory and (2) compare the performance of these two materials in repairing an immediate iatrogenic furcal perforation of primary molars both clinically and radiographically.
In vitro sections including eighty mandibular second primary molars were sorted into 4 equal groups: (1) an intact furcation area group, (2) an artificial perforation group (unrepaired), (3) an artificial perforation group repaired with MTA, and (4) an artificial perforation group repaired with premixed BC. The dye extraction method was used to assess the sealing ability of the material. Clinically, the study was designed as an equivalent parallel randomized controlled trial. Seventy-six mandibular second primary molars with immediate furcal perforation were sealed with MTA and premixed BC. Teeth were evaluated clinically and radiographically at 3, 6, and 12 months.
Although the difference was statistically insignificant (p = 0.058), the premixed BC group had better sealing ability than the MTA group [mean difference = 0.020; 95% CI (-0.001, 0.040)]. Clinically and radiographically, the two materials had an equivalent success rate in the first 3 months [ARR = 0.05; 95% CI (-0.07, 0.17)] but inequivalent success rates at 6 and 12 months with premixed BC performing better than MTA.
The present findings confirm that premixed BC is a promising material that can be used to repair a furcal perforation of primary molars. Premixed BC has better sealing properties and better performance at the clinical and radiographic levels than MTA.
(1) Accidental furcal perforation in primary molars is one of the worst problems that results in diminishing the lifetime expectancy of primary teeth if not properly treated. Though new BC repair materials have been introduced to enhance healing and tissue inductive properties, there is an obvious shortage in clinical trials covering this area. The present study is a premier study that assesses a recently introduced premixed BC material in the furcal perforation of primary teeth and compares its outcomes with those of the widely used MTA.
ClinicalTrials.gov PRS reference #NCT04137861.
本研究旨在：(1) 评估预混生物陶瓷（BC）和矿化三氧化物凝聚体（MTA）在实验室中的封闭性能；(2) 比较这两种材料在修复下颌第二乳磨牙即刻医源性根分叉穿孔方面的临床和影像学表现。
体外切片包括 80 颗下颌第二乳磨牙，分为 4 组：(1) 完整分叉区组；(2) 人工穿孔组（未修复）；(3) MTA 修复人工穿孔组；(4) 预混 BC 修复人工穿孔组。采用染料提取法评估材料的封闭能力。临床研究设计为等效平行随机对照试验。76 颗下颌第二乳磨牙即刻发生根分叉穿孔，用 MTA 和预混 BC 封闭。分别于 3、6、12 个月进行临床和影像学评估。
尽管差异无统计学意义（p=0.058），但预混 BC 组的封闭效果优于 MTA 组[平均差异=0.020；95%置信区间（-0.001，0.040）]。在最初的 3 个月内，两种材料的临床和影像学成功率相当[ARR=0.05；95%置信区间（-0.07，0.17）]，但在 6 和 12 个月时的成功率不同，预混 BC 组的效果优于 MTA 组。
本研究结果证实，预混 BC 是一种有前途的材料，可用于修复乳磨牙根分叉穿孔。预混 BC 在封闭性能和临床及影像学效果方面优于 MTA。
(1) 下颌乳磨牙意外根分叉穿孔是导致乳磨牙寿命缩短的最严重问题之一，如果处理不当。虽然已经引入了新的 BC 修复材料来增强愈合和组织诱导特性，但在涵盖这一领域的临床试验中仍存在明显的不足。本研究是一项评估最近引入的预混 BC 材料在乳磨牙根分叉穿孔中的应用，并将其结果与广泛使用的 MTA 进行比较的研究。
ClinicalTrials.gov PRS 参考号 NCT04137861。
