Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg, Germany.
Int J Cardiovasc Imaging. 2021 Jun;37(6):2011-2023. doi: 10.1007/s10554-021-02160-z. Epub 2021 Jan 22.
Cardiovascular magnetic resonance (CMR) is the reference standard for the quantitative assessment of cardiac morphology and function. The aim of the study was to determine age- and gender-related reference values for cardiac morphology and function according to current recommendations. 454 healthy volunteers (235 men, median age 52.0 (44.0-59.0) years) underwent a standard CMR scan and were divided into six groups of nearly equal size with regard to sex (male, female) and age (21-47 years, 48-57 years, 58-84 years). Left ventricular end-diastolic (LV-EDV) and end-systolic (LV-ESV) volumes and LV mass (LV-M) were measured at end-diastole and end-systole in steady-state free precession series with including papillary muscles and trabecular tissue in the LV-M. Absolute and indexed volumetric parameters were significantly different between gender groups with higher values in men compared to women (all p < 0.001). Furthermore, a significant age-dependent decline could be observed for left ventricular and right ventricular volumes (all p < 0.001), while LV-M did not show differences between the different age-groups. Parameters of longitudinal function for the left and right ventricle were higher in female compared to male subjects with a significant age-dependent decline. We provided normal values for cardiac volumes, function, and mass derived in accordance with current guidelines from a large population of healthy subjects, which can be implemented in clinical routine as a standard of reference.
心血管磁共振（CMR）是心脏形态和功能定量评估的参考标准。本研究的目的是根据当前的建议，确定与年龄和性别相关的心脏形态和功能参考值。454 名健康志愿者（235 名男性，中位年龄 52.0（44.0-59.0）岁）接受了标准的 CMR 扫描，并根据性别（男性、女性）和年龄（21-47 岁、48-57 岁、58-84 岁）分为六个大小几乎相等的组。在稳态自由进动序列中，在舒张末期和收缩末期测量左心室舒张末期（LV-EDV）和收缩末期（LV-ESV）容积和左心室质量（LV-M），包括乳头肌和小梁组织在内的 LV-M。绝对和指数容积参数在性别组之间存在显著差异，男性的数值高于女性（均 p<0.001）。此外，还可以观察到左心室和右心室容积随年龄的显著下降（均 p<0.001），而 LV-M 在不同年龄组之间没有差异。与男性相比，女性的左、右心室纵向功能参数较高，且随年龄呈显著下降趋势。我们根据当前的指南，从大量健康受试者中提供了符合指南的心脏容积、功能和质量的正常参考值，这些参考值可在临床常规中作为标准实施。
