多民族人群中的正常性别和年龄特异性参数：加拿大心脏和思维健康联盟队列的心血管磁共振研究。
Normal sex and age-specific parameters in a multi-ethnic population: a cardiovascular magnetic resonance study of the Canadian Alliance for Healthy Hearts and Minds cohort.
机构信息
Division of Cardiology, Department of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
出版信息
J Cardiovasc Magn Reson. 2022 Jan 3;24(1):2. doi: 10.1186/s12968-021-00819-z.
BACKGROUND
Despite the growing utility of cardiovascular magnetic resonance (CMR) for cardiac morphology and function, sex and age-specific normal reference values derived from large, multi-ethnic data sets are lacking. Furthermore, most available studies use a simplified tracing methodology. Using a large cohort of participants without history of cardiovascular disease (CVD) or risk factors from the Canadian Alliance for Healthy Heart and Minds, we sought to establish a robust set of reference values for ventricular and atrial parameters using an anatomically correct contouring method, and to determine the influence of age and sex on ventricular parameters.
METHODS AND RESULTS
Participants (n = 3206, 65% females; age 55.2 ± 8.4 years for females and 55.1 ± 8.8 years for men) underwent CMR using standard methods for quantitative measurements of cardiac parameters. Normal ventricular and atrial reference values are provided: (1) for males and females, (2) stratified by four age categories, and (3) for different races/ethnicities. Values are reported as absolute, indexed to body surface area, or height. Ventricular volumes and mass were significantly larger for males than females (p < 0.001). Ventricular ejection fraction was significantly diminished in males as compared to females (p < 0.001). Indexed left ventricular (LV) end-systolic, end-diastolic volumes, mass and right ventricular (RV) parameters significantly decreased as age increased for both sexes (p < 0.001). For females, but not men, mean LV and RVEF significantly increased with age (p < 0.001).
CONCLUSION
Using anatomically correct contouring methodology, we provide accurate sex and age-specific normal reference values for CMR parameters derived from the largest, multi-ethnic population free of CVD to date.
CLINICAL TRIAL REGISTRATION
ClinicalTrials.gov, NCT02220582. Registered 20 August 2014-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02220582 .
背景
尽管心血管磁共振（CMR）在心脏形态和功能方面的应用越来越广泛，但缺乏来自大型多民族数据集中的针对性别和年龄的正常参考值。此外，大多数现有研究使用简化的追踪方法。本研究使用来自加拿大健康心脏和大脑联盟（Canadian Alliance for Healthy Heart and Minds）的无心血管疾病（CVD）或危险因素的大量参与者队列，旨在使用解剖学正确的轮廓方法为心室和心房参数建立一组可靠的参考值，并确定年龄和性别对心室参数的影响。
方法和结果
参与者（n=3206，女性占 65%；女性年龄为 55.2±8.4 岁，男性为 55.1±8.8 岁）使用标准方法进行 CMR 检查，以进行心脏参数的定量测量。提供了正常的心室和心房参考值：（1）适用于男性和女性，（2）按四个年龄组分层，（3）适用于不同种族/民族。值以绝对值、体表面积指数或身高指数表示。男性的心室容积和质量明显大于女性（p<0.001）。与女性相比，男性的心室射血分数明显降低（p<0.001）。对于两性，左心室（LV）收缩末期和舒张末期容积、质量和右心室（RV）参数的指数均随年龄增长而显著降低（p<0.001）。对于女性，但不是男性，平均 LV 和 RVEF 随年龄增加而显著增加（p<0.001）。
结论
使用解剖学正确的轮廓方法，我们为迄今为止最大的、多民族的无 CVD 人群提供了 CMR 参数的准确性别和年龄特异性正常参考值。
临床试验注册
ClinicalTrials.gov，NCT02220582。注册于 2014 年 8 月 20 日-回顾性注册，https://clinicaltrials.gov/ct2/show/NCT02220582。
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