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Environ Sci Pollut Res Int. 2021 Jun;28(21):26537-26544. doi: 10.1007/s11356-021-12493-w. Epub 2021 Jan 23.
Data (N = 2552) from National Health and Nutrition Examination Survey for US adults aged ≥ 20 years for 2011-2016 were analyzed to estimate the associations between the concentrations of blood cadmium, lead, and total mercury and the concentrations of seven perfluoroalkyl acids (PFAA), namely, 2-(N-Methyl-perfluorooctane sulfonamido) acetic acid (MPAH), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS). Concentrations of blood cadmium were negatively associated with the concentrations of PFHxS (β = - 0.05428, p < 0.01) and PFOS (β = - 0.0212, p = 0.02). Concentrations of blood lead were positively associated with the concentrations of MPAH (β = 0.03301, p < 0.01), PFOA (β = 0.04783, p = 0.01), PFNA (β = 0.11761, p < 0.01), PFDA (β = 0.08007, p < 0.01), PFUA (β = 0.11382, p < 0.01), and PFOS (β = 0.04996, p = 0.02). Percent increases in the concentration of blood lead were 0.32%, 0.46%, 1.13%, 0.77%, 1.09%, and 0.48% for 10% increases in the concentrations of MPAH, PFOA, PFNA, PFDA, PFUA, and PFOS, respectively. Concentrations of blood total mercury were positively associated with the concentrations of PFNA (β = 0.37105, p < 0.01), PFDA (β = 0.46875, p < 0.01), PFUA (β = 0.56934, p < 0.01), and PFOS (β = 0.17557, p < 0.01). Percent increases in the concentration of blood total mercury were 3.6%, 4.57%, 5.58%, and 1.69% for 10% increases in the concentrations of PFNA, PFDA, PFUA, and PFOS, respectively. Associations between the concentrations of PFAAs with blood total mercury were substantially stronger than the concentrations with blood lead. Higher the carbon chain length for PFAAs, stronger were the associations between PFAAs with lead and mercury.
对美国≥ 20 岁成年人的 2011-2016 年国家健康和营养检查调查的数据（N = 2552）进行了分析，以估计血液中镉、铅和总汞浓度与七种全氟烷基酸（PFAA）浓度之间的关联，即 2-（N-甲基-全氟辛烷磺酰胺基）乙酸（MPAH）、全氟辛酸（PFOA）、全氟壬酸（PFNA）、全氟癸酸（PFDA）、全氟十一烷酸（PFUnDA）、全氟己烷磺酸（PFHxS）和全氟辛烷磺酸（PFOS）。血液中镉浓度与 PFHxS（β=-0.05428，p<0.01）和 PFOS（β=-0.0212，p=0.02）浓度呈负相关。血液中铅浓度与 MPAH（β=0.03301，p<0.01）、PFOA（β=0.04783，p=0.01）、PFNA（β=0.11761，p<0.01）、PFDA（β=0.08007，p<0.01）、PFUA（β=0.11382，p<0.01）和 PFOS（β=0.04996，p=0.02）浓度呈正相关。血液中铅浓度每增加 10%，血液中 MPAH、PFOA、PFNA、PFDA、PFUA 和 PFOS 的浓度分别增加 0.32%、0.46%、1.13%、0.77%、1.09%和 0.48%。血液中总汞浓度与 PFNA（β=0.37105，p<0.01）、PFDA（β=0.46875，p<0.01）、PFUA（β=0.56934，p<0.01）和 PFOS（β=0.17557，p<0.01）浓度呈正相关。血液中总汞浓度每增加 10%，PFNA、PFDA、PFUA 和 PFOS 的浓度分别增加 3.6%、4.57%、5.58%和 1.69%。全氟烷基酸（PFAAs）与血液总汞浓度之间的关联强度明显强于与血液铅浓度之间的关联，而 PFAAs 的碳链长度越高，与铅和汞之间的关联就越强。
