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经阴道颊黏膜瓣尿道成形术治疗女性尿道狭窄。

Ventral onlay buccal mucosa graft urethroplasty for female urethral stricture.

机构信息

Department of Urology, Gulhane Training and Research Hospital, Ankara, Turkey.

出版信息

Int J Urol. 2021 May;28(5):538-543. doi: 10.1111/iju.14504. Epub 2021 Jan 22.

Abstract

OBJECTIVES

Female urethral stricture is a rare disease. Urethroplasty with different techniques using grafts or flaps are successful treatment options. The objective of this study was to present our experience with ventral onlay buccal mucosa graft urethroplasty for the treatment of female urethral stricture disease.

METHODS

Eight female patients treated with ventral onlay buccal mucosa graft urethroplasty were identified retrospectively. Patient evaluation included physical examination, uroflowmetry with postvoid residual urine measurement, videourodynamics and urethrocystoscopy. Stricture was identified by videourethrography and/or urethrocystoscopy. Urodynamic evidence of stricture was considered as a persistent low maximum flow rate of <12 mL/s combined with detrusor pressure at maximum measured flow rate of >20 cmH O in the pressure flow study.

RESULTS

The mean age was 50.5 ± 4.14 years. Stricture etiology was idiopathic (62.5%) or iatrogenic (37.5%). Two patients (25%) had undergone prior urethral dilations before buccal mucosa graft urethroplasty. Mean stricture length was 1.62 ± 0.44 cm. Stricture location was as follows: four distal urethra (50%), two mid-distal (25%) and two mid-urethra (25%). The mean postoperative follow-up period was 16.37 ± 5.75 months, and the during follow-up success rate was 100%. No complication, such as incontinence or vaginal fistula, was noted, except dyspareunia developed in one patient (12.5%).

CONCLUSIONS

Ventral onlay buccal mucosa graft urethroplasty is a safe and effective treatment option for female urethral stricture. Unnecessary dilation should not be carried out and buccal mucosa graft urethroplasty in expert centers should be recommended to these patients.

摘要

目的

女性尿道狭窄是一种罕见疾病。采用移植物或皮瓣的不同技术的尿道成形术是成功的治疗选择。本研究的目的是介绍我们使用腹侧黏膜下尿道成形术治疗女性尿道狭窄疾病的经验。

方法

回顾性识别了 8 名接受腹侧黏膜下尿道成形术的女性患者。患者评估包括体格检查、尿流率测量(包括残余尿量)、视频尿动力学和尿道膀胱镜检查。通过视频尿道造影和/或尿道膀胱镜检查确定狭窄。尿动力学狭窄的证据被认为是持续的低最大流量<12ml/s,结合压力流研究中最大测量流量时逼尿肌压力>20cmH2O。

结果

平均年龄为 50.5±4.14 岁。狭窄病因是特发性(62.5%)或医源性(37.5%)。2 名患者(25%)在接受颊黏膜移植物尿道成形术之前接受过尿道扩张。平均狭窄长度为 1.62±0.44cm。狭窄部位如下:4 例(50%)位于远端尿道,2 例(25%)位于中远端尿道,2 例(25%)位于中尿道。平均术后随访时间为 16.37±5.75 个月,随访成功率为 100%。除 1 名患者(12.5%)出现性交困难外,无并发症,如尿失禁或阴道瘘。

结论

腹侧黏膜下尿道成形术是治疗女性尿道狭窄的一种安全有效的治疗选择。不应该进行不必要的扩张,应该向这些患者推荐在专家中心进行颊黏膜移植物尿道成形术。

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