Department of Dermatology, Andrology & STDs, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt.
Health Sector, Ministry of Health & Population, Shebin El Kom, Egypt.
J Cosmet Dermatol. 2021 Sep;20(9):2981-2988. doi: 10.1111/jocd.13947. Epub 2021 Jan 22.
Psoriasis is considered as an immune-mediated disorder with significant epidermal hyperplasia and inflammation. Cysteine-rich angiogenic inducer 61 (CYR61), known as CCN family member 1 (CCN1), plays an important role in cell proliferation and neovascularization which may trigger psoriasis development.
This study aimed to assess the immunostaining of CYR61 in psoriatic skin (lesional and perilesional) compared to control skin.
PATIENTS/METHODS: This is a case-control study. The Psoriasis Area and Severity Index (PASI) was used to evaluate disease severity. A punch biopsy was taken from psoriatic skin lesions (30), perilesional (30) skin, and matched site of controls (20). The pathological and immunostaining assessments of CYR61 were conducted.
There was a significant gradual progressive overexpression of CYR61 in keratinocytes from control skin to perilesional and lesional psoriatic skin (P = .00). Moreover, lesional psoriatic skin showed overexpression of CYR61 in inflammatory cells in the dermis than controls. CYR61 expression (lesional epidermis) revealed a significant positive correlation with the PASI score (r = .63; P = .00). There was a significant relationship between intensity and H-core of CYR61 in the lesional psoriatic epidermis with joint affection.
CYR61 may trigger epidermal hyperplasia and potentiate inflammatory infiltration in psoriasis vulgaris patients, and therapies targeting CYR61 may be effective in the management of psoriasis vulgaris.
银屑病被认为是一种免疫介导的疾病，具有明显的表皮过度增生和炎症。富含半胱氨酸的血管生成诱导因子 61（CYR61），也称为细胞外基质成分 1（CCN1），在细胞增殖和新血管生成中发挥重要作用，这可能触发银屑病的发展。
本研究旨在评估 CYR61 在银屑病皮肤（皮损和皮损周围）中的免疫染色与正常皮肤相比的情况。
患者/方法：这是一项病例对照研究。采用银屑病面积和严重程度指数（PASI）评估疾病严重程度。从银屑病皮损（30 例）、皮损周围（30 例）皮肤和对照组（20 例）的匹配部位取活检。进行 CYR61 的组织病理学和免疫染色评估。
从正常皮肤到皮损周围和银屑病皮损皮肤，角质形成细胞中 CYR61 的表达呈显著逐渐过度表达（P=0.00）。此外，与对照组相比，银屑病皮损皮肤中的炎症细胞中 CYR61 的表达过度。CYR61 表达（皮损表皮）与 PASI 评分呈显著正相关（r=0.63；P=0.00）。在银屑病皮损表皮中，CYR61 的强度和 H 核心与关节受累之间存在显著的关系。
CYR61 可能触发银屑病患者表皮过度增生并增强炎症浸润，针对 CYR61 的治疗方法可能对寻常型银屑病的治疗有效。
