Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Undergraduate Neuroscience Program, University of Pennsylvania, Philadelphia, Pennsylvania.
Biophys J. 2021 Mar 2;120(5):756-763. doi: 10.1016/j.bpj.2021.01.013. Epub 2021 Jan 21.
In this perspective, we discuss the physiological roles of Na and K channels, emphasizing the importance of the K channel for cellular homeostasis in animal cells and of Na and K channels for cellular signaling. We consider the structural basis of Na and K channel gating in light of recent structural and electrophysiological findings.
在这个视角下，我们讨论了钠和钾通道的生理作用，强调了钾通道对于动物细胞内细胞稳态的重要性，以及钠和钾通道对于细胞信号转导的重要性。我们结合最近的结构和电生理发现，讨论了钠和钾通道门控的结构基础。
