Department for Hygiene, Social and Environmental Medicine, MA 1/31, Ruhr-University Bochum, Universitätsstrasse 150, 44801, Bochum, Germany.
Department for Hygiene, Social and Environmental Medicine, MA 1/31, Ruhr-University Bochum, Universitätsstrasse 150, 44801, Bochum, Germany.
Regul Toxicol Pharmacol. 2021 Apr;121:104868. doi: 10.1016/j.yrtph.2021.104868. Epub 2021 Jan 21.
For evaluation of internal exposure to harmful substances, the Human Biomonitoring Commission of the German Environment Agency (HBM Commission) develops toxicologically justified assessment values (HBM-I and HBM-II). The HBM-I value corresponds to the concentration of a compound in human biological material below which no adverse health effects are expected to occur. Consequently, no action is required when the HBM-I value is not exceeded (HBM-Commission, 1996). In 2016, the HBM Commission developed HBM-I values of 2 ng PFOA/mL and 5 ng PFOS/mL in blood serum or plasma, respectively. A detailed delineation of supporting arguments was published in April 2018 (HBM-Commission, 2018). In contrast to the HBM-I, the HBM-II value corresponds to the concentration in human biological material which, when exceeded, may lead to health impairment which is considered as relevant to exposed individuals (HBM-Commission, 1996, HBM-Commission, 2014). HBM-II VALUES FOR PFOA AND PFOS: On September 17, 2019, the HBM Commission of the German Environment Agency established the following HBM-II values: Women at child-bearing age: 5 ng PFOA/mL blood plasma; 10 ng PFOS/mL blood plasma; All other population groups: 10 ng PFOA/mL blood plasma; 20 ng PFOS/mL blood plasma.
为了评估有害物质的内部暴露，德国环境署人体生物监测委员会（HBM 委员会）制定了具有毒理学依据的评估值（HBM-I 和 HBM-II）。HBM-I 值对应于人体生物材料中化合物的浓度，如果低于该浓度，则预计不会发生不良健康影响。因此，当 HBM-I 值未超过时，不需要采取行动（HBM 委员会，1996 年）。2016 年，HBM 委员会分别制定了血清或血浆中 2ng PFOA/mL 和 5ng PFOS/mL 的 HBM-I 值。支持论点的详细说明于 2018 年 4 月发布（HBM 委员会，2018 年）。与 HBM-I 不同，HBM-II 值对应于人体生物材料中的浓度，如果超过该浓度，可能会导致被认为与暴露个体相关的健康损害（HBM 委员会，1996 年，HBM 委员会，2014 年）。PFOA 和 PFOS 的 HBM-II 值：2019 年 9 月 17 日，德国环境署人体生物监测委员会确定了以下 HBM-II 值：育龄妇女：5ng PFOA/mL 血浆；10ng PFOS/mL 血浆；所有其他人群：10ng PFOA/mL 血浆；20ng PFOS/mL 血浆。
