Byun Jung-Ick, Cha Kwang Su, Kim Minah, Lee Woo-Jin, Lee Han Sang, Sunwoo Jun-Sang, Shin Jung-Won, Kim Tae-Joon, Moon Jangsup, Lee Soon-Tae, Jung Keun-Hwa, Chu Kon, Kim Man-Ho, Kim Han-Joon, Shin Won Chul, Lee Sang Kun, Jung Ki-Young
Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, South Korea.
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Sleep Med. 2021 Mar;79:88-93. doi: 10.1016/j.sleep.2020.12.038. Epub 2021 Jan 2.
Functional connectivity (FC) changes can occur prior to structural changes. This study aimed to evaluate data-driven whole-brain FC associated with isolated rapid eye movement sleep behavior disorder (iRBD) using multivariate pattern analysis (MVPA).
This was a cross-sectional study of 50 polysomnography-confirmed iRBD patients and 20 age- and sex-matched controls. We used MVPA implemented in the connectome-MVPA CONN toolbox to identify data-driven seed regions for post hoc seed-to-voxel connectivity analysis. The association between FC changes and clinical characteristics, including cognition, depression, autonomic function, and daytime sleepiness, was evaluated.
MVPA revealed one significant cluster located in the left posterior insular cortex. Seed-to-voxel FC analysis using the cluster as a seed showed significantly reduced FC with two clusters located in the precuneus in iRBD patients compared to the controls. The degree of FC was associated with the Montreal Cognitive Assessment-Korean version scores (r = 0.317, p = 0.025).
This study emphasizes the insula as an important neural correlate associated with iRBD that was associated with cognitive function.
功能连接（FC）变化可能先于结构变化出现。本研究旨在使用多变量模式分析（MVPA）评估与孤立性快速眼动睡眠行为障碍（iRBD）相关的数据驱动全脑功能连接。
这是一项横断面研究，纳入了50例经多导睡眠图确诊的iRBD患者和20例年龄及性别匹配的对照。我们使用连接组-MVPA CONN工具箱中实现的MVPA来识别用于事后种子到体素连接分析的数据驱动种子区域。评估了功能连接变化与包括认知、抑郁、自主神经功能和日间嗜睡在内的临床特征之间的关联。
MVPA显示一个显著簇位于左侧岛叶后部皮质。以该簇为种子进行的种子到体素功能连接分析显示，与对照组相比，iRBD患者中与楔前叶的两个簇的功能连接显著降低。功能连接程度与蒙特利尔认知评估-韩语版评分相关（r = 0.317，p = 0.025）。
本研究强调岛叶是与iRBD相关的重要神经关联，且与认知功能有关。
