College of Medicine and Public Health, Flinders University, Sturt Road, Bedford Park, South Australia 5042, Australia.
Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Mark Oliphant Building, 5 Laffer Drive, Bedford Park, South Australia 5042, Australia.
Sleep Med Clin. 2021 Mar;16(1):1-10. doi: 10.1016/j.jsmc.2020.10.001. Epub 2020 Dec 2.
Although good adherence to continuous positive airway pressure (PAP) traditionally is defined as greater than or equal to 4 hours/night, the origins and rationale for this remain unclear. Research studies report variation in optimal duration of PAP adherence, depending on outcome of interest. Evidence demonstrates benefit with PAP for daytime sleepiness, quality of life, neurocognitive outcomes, depression, and hypertension, predominantly in symptomatic, moderate-severe obstructive sleep apnea. Recent randomized controlled trials, however, have failed to demonstrate a reduction in cardiovascular and mortality risks. This review explores the question of what can be considered a clinically meaningful outcome for PAP adherence.
尽管传统上认为良好的持续气道正压通气（PAP）依从性定义为每晚大于或等于 4 小时，但这种定义的起源和依据尚不清楚。研究报告显示，根据关注的结果，PAP 依从性的最佳持续时间存在差异。证据表明，PAP 对白天嗜睡、生活质量、神经认知结果、抑郁和高血压有好处，主要是对有症状的中重度阻塞性睡眠呼吸暂停患者。然而，最近的随机对照试验未能证明心血管和死亡风险降低。本综述探讨了什么可以被认为是 PAP 依从性的临床有意义的结果的问题。
