Department of Biobehavioral Health Science, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Claire Fagin Hall, Room 349, Philadelphia, PA 19104, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; University of Pennsylvania Perelman School of Medicine, Center for Sleep and Circadian Neurobiology, Philadelphia, PA, USA.
Department of Neurology, Sleep Medicine Division, University of Miami Miller School of Medicine, 1201 Northwest 16th Street, Room A212, Miami, FL 33125, USA; Miami Veterans Affairs HealthCare System, Miami, FL, USA.
Sleep Med Clin. 2021 Mar;16(1):125-144. doi: 10.1016/j.jsmc.2020.10.007. Epub 2020 Dec 15.
Large-scale randomized trials of positive airway pressure (PAP) efficacy have been largely negative but PAP adherence was notably suboptimal across the trials. To address this limitation, evidence-based PAP adherence protocols embedded within the larger trial protocol are recommended. The complexity of such protocols depends on adequacy of resources, including funding and inclusion of behavioral scientist experts on the scientific team, and trial-specific considerations (eg, target population) and methods. Recommendations for optimizing PAP adherence in large-scale trials are set forth that address rigor and reproducibility.
大规模的气道正压通气（PAP）疗效随机试验结果大多为阴性，但各试验中 PAP 的依从性明显较差。为了解决这一局限性，建议在更大规模的试验方案中嵌入基于证据的 PAP 依从性方案。这些方案的复杂性取决于资源的充足性，包括资金以及在科学团队中纳入行为科学家专家，还取决于特定试验的考虑因素（例如目标人群）和方法。本文提出了一系列旨在提高大规模试验中 PAP 依从性的建议，以确保研究的严谨性和可重复性。
