Moghadasi Abdorreza Naser, Mirmosayyeb Omid, Mohammadi Aida, Sahraian Mohammad Ali, Ghajarzadeh Mahsa
Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran.
Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Universal council of epidemiology (UCE), universal scientific education and research network (USERN), Tehran University of medical sciences, Tehran, Iran.
Mult Scler Relat Disord. 2021 Apr;49:102757. doi: 10.1016/j.msard.2021.102757. Epub 2021 Jan 15.
To estimate pooled prevalence of cognitive impairment in neuromyelitis opticaspectrum disorders (NMOSD) cases.
We searched PubMed, Scopus, EMBASE, Web of Science, and google scholar. We also searched the gray literature including references of the included studies, and conference abstracts which were published up to 20th October 2020. The search strategy included the MeSH and text words as (((Cognitive Dysfunctions) OR Cognitive Impairment) OR Cognitive Declines) OR Mild Cognitive Impairment) OR Mental Deterioration) AND (Neuromyelitis Optica spectrum disorder OR NMOSD OR Devic syndrome OR Neuromyelitis Optica spectrum disorders).
The literature search revealed 1830 articles, after deleting duplicates 1434 remained. For the meta-analysis, 25 studies were included. Totally, 761 NMOSD patients were evaluated and 329 patients had cognitive impairment. Mean age ranged from 34-53 years. The prevalence of cognitive impairment ranged from 3% to 75%.The pooled prevalence of cognitive impairment was 44%, 95%CI(35%-54%), (I=89.1%, P<0.001) which shows a high statistical heterogeneity . By excluding the abstract of Jung et al which was published in 2009, we found that the pooled prevalence was 34% (95% CI:31-37%) (I=0) CONCLUSION: Cognitive impairment should be considered in NMOSD patients as its pooled prevalence is estimated as 44%.
评估视神经脊髓炎谱系障碍（NMOSD）患者认知障碍的合并患病率。
我们检索了PubMed、Scopus、EMBASE、Web of Science和谷歌学术。我们还检索了灰色文献，包括纳入研究的参考文献以及截至2020年10月20日发表的会议摘要。检索策略包括医学主题词（MeSH）和文本词，即（（（认知功能障碍）或认知损害）或认知衰退）或轻度认知损害）或智力衰退）且（视神经脊髓炎谱系障碍或NMOSD或德维克综合征或视神经脊髓炎谱系疾病）。
文献检索共找到1830篇文章，删除重复项后剩余1434篇。纳入荟萃分析的有25项研究。总共评估了761例NMOSD患者，其中329例有认知障碍。平均年龄在34至53岁之间。认知障碍的患病率在3%至75%之间。认知障碍的合并患病率为44%，95%置信区间（35%-54%），（I²=89.1%，P<0.001），显示出高度的统计学异质性。排除2009年发表的Jung等人的摘要后，我们发现合并患病率为34%（95%置信区间：31-37%）（I²=0）。结论：NMOSD患者应考虑存在认知障碍，因为其合并患病率估计为44%。
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