严重急性呼吸综合征冠状病毒2（SARS-CoV-2）宏结构域的核磁共振（NMR）归属
NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
作者信息
Lin Meng-Hsuan, Huang Yi-Ping, Chang Chi-Fon, Hsu Chun-Hua
机构信息
Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei, 10617, Taiwan.
Genomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.
出版信息
Biomol NMR Assign. 2021 Apr;15(1):137-142. doi: 10.1007/s12104-020-09996-x. Epub 2021 Jan 24.
Abstract
SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and initiating viral replication. Here, we report the H, C, and N resonance assignments of the SARS-CoV-2 macro domain. This work provides the ground for further structural deciphering and biophysical investigation in protein function and antiviral agent design.
摘要
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是一种新型病原体，自2019年底以来引发了名为2019冠状病毒病（COVID-19）的肺炎，并导致了一场严重的全球大流行。SARS-CoV-2的基因组包含一个宏观结构域，该结构域可能在调节宿主细胞中的ADP核糖基化以及启动病毒复制方面发挥重要作用。在此，我们报告了SARS-CoV-2宏观结构域的氢、碳和氮共振归属。这项工作为进一步的结构解析以及蛋白质功能和抗病毒药物设计的生物物理研究奠定了基础。
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