Agrilucent, Greenfield, IN, USA.
Agranova, Orpington, UK.
Pest Manag Sci. 2021 Aug;77(8):3608-3616. doi: 10.1002/ps.6293. Epub 2021 Feb 18.
The Industry responsible for the discovery and development of crop protection compounds has undergone dramatic changes and increasing consolidation since the initial innovations in synthetic organic fungicides, herbicides and insecticides in the late 1940s and early 1950s. Likewise, there have been striking changes in the rate of introduction of new crop protection compounds over the past 70 years. While numerous studies over the past five decades have signaled the ongoing decline in the numbers of new active ingredients (AIs), a detailed analysis of the trends in the rate of introduction of crop protection compounds shows a more complex pattern in the overall output of new AIs. The recent (post-2000) decline in the numbers of new herbicides is the primary source of the perceived decline in overall numbers. When herbicides are excluded, the output of new fungicides and insecticides has been relatively constant, especially for the past 20 years. A notable observation is that innovation, as measured by the number of compounds representing a new chemical class (First-in-Class) has been relatively constant for the past 70 years, and most recently has been driven by the appearance of new fungicides and insecticides. Thus, the discovery and development of new AIs for crop protection and public health continues, in spite of the many challenges and changes to the Industry. © 2021 Society of Chemical Industry.
自 20 世纪 40 年代末和 50 年代初合成有机杀菌剂、除草剂和杀虫剂的最初创新以来，负责发现和开发作物保护化合物的行业发生了巨大变化和日益整合。同样，在过去的 70 年里，新的作物保护化合物的引入速度也发生了显著变化。虽然过去五十年的众多研究表明新有效成分 (AI) 的数量持续下降，但对引入作物保护化合物的趋势的详细分析表明，新 AI 的总体产量呈现出更为复杂的模式。近年来（2000 年后）新除草剂数量的减少是整体数量减少的主要原因。当不考虑除草剂时，新杀菌剂和杀虫剂的产量相对稳定，尤其是在过去 20 年。值得注意的是，创新（以代表新化学类别的化合物数量衡量）在过去 70 年中相对稳定，最近主要由新杀菌剂和杀虫剂的出现推动。因此，尽管行业面临诸多挑战和变化，用于作物保护和公共卫生的新 AI 的发现和开发仍在继续。© 2021 英国化学工业协会。
