Department of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
J Cosmet Dermatol. 2021 Sep;20(9):2723-2728. doi: 10.1111/jocd.13941. Epub 2021 Jan 23.
Localized scleroderma (LoS) is a rare autoimmune disease characterized by skin fibrosis and subcutaneous tissue atrophy, resulting in aesthetic impairment on patients. Fat grafting has been used to treat LoS patients, achieving aesthetic and therapeutic improvement.
This article summarized the epidemiology and pathophysiology of LoS and the current progress and thorny questions of basic and clinical research on fat grafting treating LoS.
The literature of the last 20 years concerning fat grafting of treating LoS was reviewed.
Fat grafting has been proved to produce aesthetic and therapeutic outcomes on LoS patients, including the improvement of soft tissue atrophy, skin fibrosis and pigmentation. Due to the inflammatory microenvironment of scleroderma, however, fat grafting still faces many difficulties, such as low fat retention. Novel fat grafting methods in order to supplement the deficiency of adipose-derived stem cells and improve fat retention in LoS groups have been proposed whose effectiveness and feasibility is still needed further study.
Currently, fat grafting has been regarded as an effective treatment with a combination of aesthetic and therapeutic outcomes on LoS patients.
局限性硬皮病（LoS）是一种罕见的自身免疫性疾病，其特征为皮肤纤维化和皮下组织萎缩，导致患者的美观受损。脂肪移植已被用于治疗 LoS 患者，可实现美容和治疗效果的改善。
本文总结了 LoS 的流行病学和发病机制，以及脂肪移植治疗 LoS 的基础和临床研究的最新进展和难题。
对过去 20 年有关脂肪移植治疗 LoS 的文献进行了回顾。
脂肪移植已被证明可使 LoS 患者获得美容和治疗效果，包括改善软组织萎缩、皮肤纤维化和色素沉着。然而，由于硬皮病的炎症微环境，脂肪移植仍然面临许多困难，例如脂肪保留率低。为了弥补脂肪来源干细胞的不足并提高 LoS 患者的脂肪保留率，提出了一些新的脂肪移植方法，但其有效性和可行性仍需要进一步研究。
目前，脂肪移植已被认为是一种有效的治疗方法，可同时改善 LoS 患者的美容和治疗效果。
Zotero 插件