Echevarria Cruz Evelyn C, Heyer Brooke E, Moenster Jamie M
Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, USA.
Plastic Surgery, Dermatology and Plastic Surgery of Arizona, Tucson, USA.
Cureus. 2025 Mar 21;17(3):e80977. doi: 10.7759/cureus.80977. eCollection 2025 Mar.
Parry-Romberg syndrome (PRS) is a rare craniofacial disorder marked by progressive unilateral facial atrophy. This case report presents a unique instance of PRS presenting in a 52-year-old female who was diagnosed at age 47 as the syndrome's usual onset is during the first two decades of life. The patient exhibited severe soft-tissue atrophy on the right side of the face, classified as type 3 PRS, along with associated symptoms such as headaches and a history of depression. The primary aesthetic intervention involved fat transfer (FT) to restore facial symmetry and contour. Postoperative outcomes improved facial aesthetics, though some volume loss was noted at the three-month follow-up. This case highlights the potential of FT as an effective and minimally invasive treatment for severe PRS. It emphasizes the importance of personalized treatment strategies and the need for further research into the long-term management of PRS, particularly in late-diagnosed cases. Further studies are needed to optimize fat grafting techniques and assess long-term outcomes in PRS management.
帕里-罗姆伯格综合征（PRS）是一种罕见的颅面疾病，其特征为进行性单侧面部萎缩。本病例报告呈现了一个独特的PRS病例，患者为一名52岁女性，在47岁时被诊断为此病，因为该综合征通常在生命的前二十年发病。患者右侧面部出现严重软组织萎缩，被归类为3型PRS，同时伴有头痛和抑郁症病史等相关症状。主要的美学干预措施是脂肪移植（FT），以恢复面部对称性和轮廓。术后结果改善了面部美观，尽管在三个月的随访中发现有一些体积损失。本病例突出了脂肪移植作为严重PRS的一种有效且微创治疗方法的潜力。它强调了个性化治疗策略的重要性以及对PRS长期管理进行进一步研究的必要性，特别是在晚期诊断的病例中。需要进一步研究以优化脂肪移植技术并评估PRS管理中的长期结果。
