Kong X Y, Hu T, Ge Y J, Zhang P, Li X Y, Song X, He S, Chen G H
Department of Sleep Disorders, Affiliated Chaohu Hospital of Anhui Medical University, Chaohu 238000, China.
Zhonghua Yi Xue Za Zhi. 2021 Jan 26;101(4):249-253. doi: 10.3760/cma.j.cn112137-20200430-01386.
To investigate the correlations of diurnal brain functional variations with serum biomarkers and objective sleep quality in patients with chronic insomnia disorder (CID). A total of 60 CID patients and 30 healthy sleep volunteers who visited Department of Sleep Disorders of Chaohu Hospital affiliated to Anhui Medical University from March 2018 to June 2019 were collected. Diurnal brain function state was evaluated by Quantitative Measurement System of Brain Functional Status, and serum concentrations of corticotropin-releasing hormone (CRH) and glial fibrous acidic protein (GFAP) were detected using enzyme-linked immunosorbent assay (ELISA). The sleep quality in the CID group was evaluated using ploysomnography (PSG) at the same time. The brain function status indicators with significant changes in CID group were acquired, and the consistency of these indicators with serum biological markers and objective sleep quality was analyzed. There were 23 males and 37 females in chronic in somnia patients; 15 males and 15 females in the healthy control group. Compared with the healthy controls, four brain function indicators of CID patients increased (brain inertia (196.0(163.0, 258.0)vs 168.5(148.8,182.5)), brain chaos (5.0(1.0, 10.0)vs 0(0,2.0)), internal concentration (31.0(13.0, 45.0)vs 2.0(0,27.5)) and endogenous anxiety (12.0(4.0, 18.0)vs 0(0,6.5)), but one indicator decreased (brain inhibitory value (47.0(32.0, 58.0)vs 59.0(46.3,66.3))) (all <0.05).The brain chaos value positively correlated with the serum GFAP level (0.374,0.006), and the brain inertia value positively correlated with the serum CRH level (0.299,0.031). The value of brain inhibition positively correlated with the sleep latency (0.284,0.042). However, the values of internal concentration negatively correlated with the sleep efficiency (=-0.276,=0.048) and the time in non-rapid eye movement sleep stage 1 (-0.341, 0.024). The brain waves of CID patients show significant changes in their brain function indicators, which are related to serum biological markers and objective sleep quality.
探讨慢性失眠障碍（CID）患者大脑功能昼夜变化与血清生物标志物及客观睡眠质量的相关性。收集2018年3月至2019年6月期间就诊于安徽医科大学附属巢湖医院睡眠障碍科的60例CID患者和30名健康睡眠志愿者。采用脑功能状态定量测量系统评估昼夜大脑功能状态，采用酶联免疫吸附测定（ELISA）法检测血清促肾上腺皮质激素释放激素（CRH）和胶质纤维酸性蛋白（GFAP）浓度。同时采用多导睡眠图（PSG）评估CID组的睡眠质量。获取CID组中发生显著变化的脑功能状态指标，并分析这些指标与血清生物标志物和客观睡眠质量的一致性。慢性失眠患者中男性23例，女性37例；健康对照组中男性15例，女性15例。与健康对照组相比，CID患者的四项脑功能指标升高（脑惰性（196.0(163.0, 258.0) 对168.5(148.8,182.5)）、脑混沌（5.0(1.0, 10.0) 对0(0,2.
