Department of Chemistry, Higher Teacher Training College, University of Bamenda, Bambili, Cameroon.
TWAS Research Unit (TRU), The University of Bamenda, Bamenda, Cameroon.
Nat Prod Res. 2022 Mar;36(5):1288-1295. doi: 10.1080/14786419.2021.1876045. Epub 2021 Jan 25.
Two -kaurene diterpenoids, -15--acetyloxy-kaur-16-en-19-oic acid (xylopic acid) and -7-oxo-kaur-16-en-19-oic acid were isolated from the fruits of . Chemical manipulation of xylopic acid yielded -kaurane derivatives , , , and . Their structures were elucidated by spectroscopic analysis, including 1 D- and 2 D-NMR spectroscopies. The antiproliferative activities of compounds , , , , and were tested on breast MCF7 and SkBr3, endometrial Ishikawa, ovarian BG-1, mesothelioma IST-MES1 and hepatocellular HepG2 human tumor cells, and on mammalian MRC-10 fibroblast cells. Ketone showed significant antiproliferative activity against MFC7 human breast cancer cells (IC = 3 ± 1 µM) and A549 pulmonary adenocarcinoma (8 ± 1 µM), that was higher than the well-known anti-cancer agent cisplatin (IC = 19 ± 3 and 15 ± 4 µM, respectively).[Formula: see text].
从 果实中分离得到两种贝壳杉二萜类化合物：-15--乙酰氧基贝壳杉-16-烯-19-酸（木酸酸）和-7-酮基贝壳杉-16-烯-19-酸。通过化学处理木酸酸得到了 - 贝壳杉衍生物 、 、 和 。通过光谱分析，包括 1D-和 2D-NMR 光谱，确定了它们的结构。对化合物 、 、 、 和 进行了体外抗增殖活性测试，包括乳腺癌 MCF7 和 SkBr3、子宫内膜 Ishikawa、卵巢 BG-1、间皮瘤 IST-MES1 和肝癌 HepG2 人肿瘤细胞，以及哺乳动物 MRC-10 成纤维细胞。酮 对人乳腺癌 MCF7 细胞（IC=3±1μM）和 A549 肺腺癌细胞（8±1μM）显示出显著的抗增殖活性，高于著名的抗癌药物顺铂（IC=19±3 和 15±4μM，分别）。[化学式：见正文]。
