Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, CNRS-Aix-Marseille University, 31 Chemin Joseph Aiguier, 13009 Marseille, France.
Aix Marseille University, CNRS, IBDM, Turing Centre for Living Systems, Marseille, France.
Philos Trans R Soc Lond B Biol Sci. 2021 Mar 15;376(1820):20190755. doi: 10.1098/rstb.2019.0755. Epub 2021 Jan 25.
Social bacteria display complex behaviours whereby thousands of cells collectively and dramatically change their form and function in response to nutrient availability and changing environmental conditions. In this review, we focus on motility, which supports spectacular transitions based on prey availability across its life cycle. A large body of work suggests that these behaviours require sensory capacity implemented at the single-cell level. Focusing on recent genetic work on a core cellular pathway required for single-cell directional decisions, we argue that signal integration, multi-modal sensing and memory are at the root of decision making leading to multicellular behaviours. Hence, may be a powerful biological system to elucidate how cellular building blocks cooperate to form sensory multicellular assemblages, a possible origin of cognitive mechanisms in biological systems. This article is part of the theme issue 'Basal cognition: conceptual tools and the view from the single cell'.
社会细菌表现出复杂的行为，成千上万的细胞集体而显著地改变它们的形态和功能，以响应营养物质的可用性和不断变化的环境条件。在这篇综述中，我们专注于运动性，它基于猎物的可用性，在其生命周期中支持壮观的转变。大量的工作表明，这些行为需要在单细胞水平上实施的感应能力。我们专注于最近关于单细胞定向决策所需的核心细胞途径的遗传工作，我们认为信号整合、多模态传感和记忆是导致细胞行为的决策的根源。因此，社会细菌可能是一个强大的生物系统，可以阐明细胞构建块如何合作形成感觉多细胞组合，这可能是生物系统中认知机制的起源。本文是主题为“基础认知：概念工具和单细胞视角”的一部分。
