Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Laryngol Otol. 2021 Jan;135(1):33-38. doi: 10.1017/S0022215120002716. Epub 2021 Jan 25.
This study aimed to evaluate the outcome of granular myringitis treatment of 1 per cent diluted vinegar ear drops or 1 per cent chloramphenicol ear drops and to assess the side effects of 1 per cent diluted vinegar.
Twenty-four patients aged over 18 years and diagnosed with granular myringitis grade I or II within 90 days of symptom onset were included. Patients were equally randomised into either the 1 per cent diluted vinegar group or the 1 per cent chloramphenicol group. Outcome of treatment and side effects were compared between groups. The main outcome measure was completely epithelialised tympanic membrane at the eight-week period.
Eleven of 12 patients treated with 1 per cent diluted vinegar had complete recovery. In the 1 per cent chloramphenicol group, 8 of 12 patients recovered. The difference between groups was not statistically significant (p = 0.156). The observed side effects of diluted vinegar included dizziness and mild external auditory canal irritation.
One per cent diluted vinegar is an interesting option for granular myringitis. Other comparative advantages of 1 per cent diluted vinegar include its low price and no induction of antimicrobial resistance.
本研究旨在评估 1%稀释醋滴或 1%氯霉素滴治疗粒状鼓膜炎的疗效，并评估 1%稀释醋的副作用。
纳入 24 例年龄大于 18 岁且在症状出现后 90 天内被诊断为 I 级或 II 级粒状鼓膜炎的患者。患者被随机分为 1%稀释醋组或 1%氯霉素组。比较两组治疗效果和副作用。主要观察指标为 8 周时鼓膜完全上皮化。
12 例接受 1%稀释醋治疗的患者中，11 例完全恢复。12 例接受 1%氯霉素治疗的患者中，8 例恢复。两组间差异无统计学意义（p=0.156）。稀释醋观察到的副作用包括头晕和轻度外耳道刺激。
1%稀释醋是治疗粒状鼓膜炎的一种有趣选择。1%稀释醋的其他比较优势包括价格低廉且不会诱导抗菌药物耐药性。
