制备含有自毁型聚碳酸酯核的球形核酸纳米粒子。
Preparation of Spherical Nucleic Acid Nanoparticles Containing a Self-immolative Poly(carbamate) Core.
机构信息
Department of Materials Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika, Tokyo, 125-8585, Japan.
Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika, Tokyo, 125-8585, Japan.
出版信息
Anal Sci. 2021 May 10;37(5):781-784. doi: 10.2116/analsci.20SCN06. Epub 2021 Jan 22.
We prepared a novel spherical nucleic acid, containing a core structure of self-immolative poly(carbamate) (PC), with aminobenzyl alcohol as a repeating unit, by conjugating an end-activated PC derivative with an amine-terminated oligoDNA on a solid support for PC-oligoDNA. Dynamic light-scattering measurements revealed a hydrodynamic diameter of 107 nm with a narrow size distribution. A fluorescent monomer with aminobenzyl alcohol is available for PC-oligoDNA synthesis to enhance the fluorescence emission by a domino-like disassembly of PC in response to various external stimuli.
我们制备了一种新型的球形核酸，其核心结构为自毁型聚碳酸酯（PC），以氨基苄醇为重复单元，通过在固体载体上将末端活化的 PC 衍生物与末端氨基化的寡 DNA 连接，得到 PC-寡 DNA。动态光散射测量显示其水动力直径为 107nm，具有较窄的粒径分布。一种带有氨基苄醇的荧光单体可用于 PC-寡 DNA 的合成，通过 PC 的级联式解组装来增强荧光发射，以响应各种外部刺激。
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