Goto Hiroyuki, Sugita Kazunari, Yamamoto Osamu
Department of Medicine of Sensory and Motor Organs, Division of Dermatology, Faculty of Medicine, Tottori University, Tottori, Japan.
Indian J Dermatol. 2020 Nov-Dec;65(6):506-509. doi: 10.4103/ijd.IJD_187_19.
A recent clinical trial has shown the efficacy of an anti-programmed death-1 (PD-1) antibody against advanced squamous cell carcinoma (SCC). The expression of PD-ligand 1 (PD-L1) in tumor cells correlates with a favorable response to anti-PD-1 therapy in various malignancies. In recent studies, it has been shown that SCC frequently expresses PD-L1. However, there has been no previous study focusing on the difference in PD-L1 expression between SCC in sun-exposed skin and that in nonsun-exposed areas.
The purpose of this study was to investigate the relationship between sun-exposure status and PD-L1 expression in patients with SCC.
We investigated 80 patients with SCC (40 patients with SCC in sun-exposed skin and 40 patients with SCC in nonsun-exposed skin) by immunohistochemical staining for PD-L1. Fisher's exact test was used for statistical analyses of the differences between the two groups.
Patients with SCC in sun-exposed skin showed a significantly higher expression level of PD-L1 in tumor cells than did patients with SCC in nonsun-exposed skin ( = 0.0133).
We found that the expression level of PD-L1 in patients with SCC in sun-exposed skin was higher than in patients with SCC in nonsun-exposed skin. Practical data are needed for appropriate applications of new therapeutic options for SCC.
最近一项临床试验显示了抗程序性死亡蛋白1（PD-1）抗体治疗晚期鳞状细胞癌（SCC）的疗效。肿瘤细胞中PD-配体1（PD-L1）的表达与各种恶性肿瘤对抗PD-1治疗的良好反应相关。在最近的研究中，已表明SCC经常表达PD-L1。然而，以前尚无研究关注暴露于阳光下皮肤的SCC与非暴露部位SCC之间PD-L1表达的差异。
本研究的目的是调查SCC患者的阳光暴露状况与PD-L1表达之间的关系。
我们通过对PD-L1进行免疫组织化学染色，调查了80例SCC患者（40例暴露于阳光下皮肤的SCC患者和40例非暴露于阳光下皮肤的SCC患者）。采用Fisher精确检验对两组之间的差异进行统计学分析。
暴露于阳光下皮肤的SCC患者肿瘤细胞中PD-L1的表达水平显著高于非暴露于阳光下皮肤的SCC患者（P = 0.0133）。
我们发现，暴露于阳光下皮肤的SCC患者中PD-L1的表达水平高于非暴露于阳光下皮肤的SCC患者。SCC新治疗方案的适当应用需要实际数据。
