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一项前瞻性开放标签随机对照试验,比较鞘内注射1%氯普鲁卡因与0.5%布比卡因用于门诊择期手术的效果。

A Prospective Open-Label Randomized Controlled Trial to Compare Intrathecal 1% 2-Chloroprocaine Versus 0.5% Bupivacaine in Ambulatory Elective Surgeries.

作者信息

Singh Balwinderjit, Anand Asha, Attri Joginder Pal

机构信息

Department of Anesthesia, PIMS, Jalandhar, Punjab, India.

Department of Anesthesia, GMC, Amritsar, Punjab, India.

出版信息

Anesth Essays Res. 2020 Apr-Jun;14(2):266-270. doi: 10.4103/aer.AER_43_20. Epub 2020 Oct 12.


DOI:10.4103/aer.AER_43_20
PMID:33487827
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7819422/
Abstract

BACKGROUND: For an outpatient surgery, an ideal anesthetic drug should have a faster onset and shorter duration of action and minimal side effects. Although Bupivacaine is a drug of choice in spinal anesthesia but is not suitable for ambulatory surgeries. We aimed to compare 1% 2-chloroprocaine (2-CP) which is considered to be a short-acting agent with 0.5% hyperbaric bupivacaine as a spinal anesthetic agent in ambulatory surgeries. MATERIALS AND METHODS: The study includes a prospective analysis of 60 patients who underwent ambulatory surgeries of <60 min and were randomly divided into two groups of 30 each: Group I - intrathecal injection of preservative-free formulation of 1% 2-CP 40 mg (4 mL) given and Group II - intrathecal injection of 0.5% hyperbaric bupivacaine 10 mg (2.0 mL) given time to reach surgical anesthesia, time for resolution of motor block, time for end of anesthesia, time to requirement of first postoperative analgesic, time to unassisted ambulation, time for micturition, and time to reach discharge readiness criteria, which were recorded. RESULTS: We observed that in the CP group, onset time is early and there was more fast regression of surgical anesthesia in the CP group resulting in less time required for unassisted ambulation and less time for discharge from the hospital. CONCLUSION: We concluded that 2-CP can be used for spinal anesthesia in shorter duration surgeries with early recovery from anesthesia and hence early discharge from the hospital.

摘要

背景:对于门诊手术而言,理想的麻醉药物应起效更快、作用持续时间更短且副作用最小。尽管布比卡因是脊髓麻醉的首选药物,但并不适用于门诊手术。我们旨在比较被认为是短效药物的1%氯普鲁卡因(2-CP)与0.5%重比重布比卡因作为门诊手术脊髓麻醉剂的效果。 材料与方法:本研究对60例行时长小于60分钟门诊手术的患者进行前瞻性分析,将其随机分为两组,每组30人:第一组——鞘内注射不含防腐剂的1%氯普鲁卡因40毫克(4毫升);第二组——鞘内注射0.5%重比重布比卡因10毫克(2.0毫升)。记录达到手术麻醉的时间、运动阻滞消退时间、麻醉结束时间、首次术后镇痛需求时间、自主行走时间、排尿时间以及达到出院准备标准的时间。 结果:我们观察到,在氯普鲁卡因组,起效时间更早,手术麻醉消退更快,导致自主行走所需时间更少,出院时间更短。 结论:我们得出结论,2-CP可用于麻醉恢复早、手术时间短的脊髓麻醉,从而可使患者更早出院。

相似文献

[1]
A Prospective Open-Label Randomized Controlled Trial to Compare Intrathecal 1% 2-Chloroprocaine Versus 0.5% Bupivacaine in Ambulatory Elective Surgeries.

Anesth Essays Res. 2020

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[5]
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[6]
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[7]
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[8]
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[10]
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引用本文的文献

[1]
Optimal local anesthetic for spinal anesthesia in patients undergoing ambulatory non-arthroplasty surgery: a systematic review and Bayesian network meta-analysis of randomized controlled trials.

Can J Anaesth. 2025-4

[2]
Impact of Short-Acting Spinal Anesthetic on Discharge from Postanesthetic Care Unit: A Retrospective Analysis.

Can J Hosp Pharm. 2025-3-12

[3]
Research trends in readiness for hospital discharge between 2002 and 2021: A bibliometric analysis.

Nurs Open. 2023-12

[4]
Randomized Controlled Study Comparing 2-Chloroprocaine and Bupivacaine for Spinal Anesthesia in Gynecological Surgeries.

Anesth Essays Res. 2022

本文引用的文献

[1]
Intrathecal 1% 2-chloroprocaine vs. 0.5% bupivacaine in ambulatory surgery: a prospective, observer-blinded, randomised, controlled trial.

Acta Anaesthesiol Scand. 2014-5

[2]
Intrathecal chloroprocaine--not yet "safe" by US FDA parameters.

Int Anesthesiol Clin. 2012

[3]
Comparison of bupivacaine and 2-chloroprocaine for spinal anesthesia for outpatient surgery: a double-blind randomized trial.

Can J Anaesth. 2011-1-4

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Spinal anesthesia with lidocaine or preservative-free 2-chlorprocaine for outpatient knee arthroscopy: a prospective, randomized, double-blind comparison.

Anesth Analg. 2007-4

[5]
Use of spinal anaesthesia in day surgery.

Curr Opin Anaesthesiol. 2006-12

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Curr Opin Anaesthesiol. 2005-10

[8]
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Reg Anesth Pain Med. 2005

[9]
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Anesth Analg. 2005-2

[10]
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Anesthesiology. 1952-5

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