预防组织型纤溶酶原激活剂介导的蛋白激酶C下调。
Prevention of the TPA-mediated down-regulation of protein kinase C.
作者信息
Grove D S, Mastro A M
机构信息
Department of Molecular and Cell Biology, Pennsylvania State University, University Park 16802.
出版信息
Biochem Biophys Res Commun. 1988 Feb 29;151(1):94-9. doi: 10.1016/0006-291x(88)90563-3.
PMID:3348799
Abstract
Protein kinase C activity in lymphocytes was down-regulated upon exposure of the cells to 12-0-tetradecanoylphorbol-13 acetate. This down-regulation was prevented by preincubating the cells with sphingosine, a reported protein kinase C inhibitor. Two other protein kinase C inhibitors, palmitoylcarnitine and phloretin, were ineffective in preventing down-regulation by the phorbol ester.
摘要
将细胞暴露于12-O-十四烷酰佛波醇-13-乙酸酯后，淋巴细胞中的蛋白激酶C活性被下调。通过用鞘氨醇（一种已报道的蛋白激酶C抑制剂）对细胞进行预孵育，可防止这种下调。另外两种蛋白激酶C抑制剂，棕榈酰肉碱和根皮素，在防止佛波酯引起的下调方面无效。
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