Yu Wen-Liang, Toh Han Siong, Liao Chia-Te, Chang Wei-Ting
Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan.
Department of Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei.
Acta Cardiol Sin. 2021 Jan;37(1):9-17. doi: 10.6515/ACS.202101_37(1).20200913A.
SARS-CoV-2 is the virus that has caused the current coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV-2 is characterized by significantly affecting the cardiovascular system of infected patients. In addition to the direct injuries caused by the virus, the subsequent cytokine storm - an overproduction of immune cells and their activating compounds - also causes damage to the heart. The development of anti-SARS-CoV-2 treatments is necessary to control the epidemic. Despite an explosive growth in research, a comprehensive review of up-to-date information is lacking. Herein, we summarize pivotal findings regarding the epidemiology, complications, and mechanisms of, and recent therapies for, COVID-19, with special focus on its cardiovascular impacts.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是引发当前2019冠状病毒病（COVID-19）大流行的病毒。SARS-CoV-2的特点是对受感染患者的心血管系统有显著影响。除了病毒造成的直接损伤外，随后的细胞因子风暴——免疫细胞及其激活化合物的过度产生——也会对心脏造成损害。开发抗SARS-CoV-2治疗方法对于控制疫情至关重要。尽管研究呈爆发式增长，但仍缺乏对最新信息的全面综述。在此，我们总结了关于COVID-19的流行病学、并发症、机制及近期治疗方法的关键发现，特别关注其对心血管的影响。
