Eskandarani Rawan M, Sawan Shaima
King Fahad Medical City, Riyadh, Saudi Arabia.
Clin Med Insights Endocrinol Diabetes. 2020 Dec 24;13:1179551420984125. doi: 10.1177/1179551420984125. eCollection 2020.
Hyperglycaemia during inpatient admission is indicative of higher morbidity and mortality risks in critically ill patients. The severe acute respiratory distress coronavirus 2 (SARS-CoV-2) has been reported to induce ketoacidosis and diabetic ketoacidosis (DKA) even in nondiabetic patients. The pathophysiology of the SARS-CoV-2 infection that can contribute to hyperglycaemia, and the exacerbated inflammatory cytokine storm can overlap with the metabolic chronic inflammatory state attributable to the metabolic syndrome, which underlies diabetes mellitus. In this report, we explore the possible pathophysiology and metabolic mechanisms that lead to metabolic acidosis in nondiabetic patients.
住院期间的高血糖表明重症患者的发病和死亡风险更高。据报道，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）即使在非糖尿病患者中也会诱发酮症酸中毒和糖尿病酮症酸中毒（DKA）。SARS-CoV-2感染导致高血糖的病理生理学，以及加剧的炎症细胞因子风暴，可能与代谢综合征所致的代谢性慢性炎症状态重叠，而代谢综合征是糖尿病的基础。在本报告中，我们探讨了导致非糖尿病患者发生代谢性酸中毒的可能病理生理学和代谢机制。
