氧化应激作为严重急性呼吸综合征冠状病毒（SARS-CoV）感染的关键因素。
Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection.
机构信息
Gerencia de Investigación Clínica, Dirección Médica, Laboratorios Liomont S.A. de C.V., Ciudad de México, México.
Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Guillermo Massieu Helguera 239, La Escalera, Gustavo A. Madero 07320, Ciudad de México, México.
出版信息
Arch Med Res. 2020 Jul;51(5):384-387. doi: 10.1016/j.arcmed.2020.04.019. Epub 2020 Apr 30.
Abstract
The emergence of viral respiratory pathogens with pandemic potential, such as severe acute respiratory syndrome coronavirus (SARS-CoV), the pathogenic agent of Covid-19, represent a serious health problem worldwide. Respiratory viral infections are, in general, associated with cytokine production, inflammation, cell death, and other pathophysiological processes, which could be link with a redox imbalance or oxidative stress. These phenomena are substantially increased during aging. Actually, severity and mortality risk of SARS-CoV-2 infection or Covid-19 disease have been associated with the age. The aim of the present work was to contribute with the understanding of the possible link between oxidative stress and the pathogenesis, severity and mortality risk in patients affected by SARS-CoV infection.
摘要
具有大流行潜力的病毒呼吸道病原体的出现，如严重急性呼吸综合征冠状病毒（SARS-CoV），是全球严重的健康问题。一般来说，呼吸道病毒感染与细胞因子产生、炎症、细胞死亡和其他病理生理过程有关，这些过程可能与氧化还原失衡或氧化应激有关。这些现象在衰老过程中会显著增加。实际上，SARS-CoV-2 感染或新冠病毒疾病的严重程度和死亡风险与年龄有关。本研究旨在探讨氧化应激与 SARS-CoV 感染患者发病机制、严重程度和死亡风险之间可能存在的联系。
相似文献
1
Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection.氧化应激作为严重急性呼吸综合征冠状病毒（SARS-CoV）感染的关键因素。
Arch Med Res. 2020 Jul;51(5):384-387. doi: 10.1016/j.arcmed.2020.04.019. Epub 2020 Apr 30.
2
Remdesivir against COVID-19 and Other Viral Diseases.瑞德西韦治疗 COVID-19 及其他病毒性疾病。
Clin Microbiol Rev. 2020 Oct 14;34(1). doi: 10.1128/CMR.00162-20. Print 2020 Dec 16.
3
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.新冠病毒、中东呼吸综合征病毒和严重急性呼吸综合征病毒在非人灵长类动物模型中的比较发病机制。
Science. 2020 May 29;368(6494):1012-1015. doi: 10.1126/science.abb7314. Epub 2020 Apr 17.
4
Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV.新兴人类致病冠状病毒 SARS-CoV、MERS-CoV 和 2019-nCoV 的病理学和发病机制的重叠和离散方面。
J Med Virol. 2020 May;92(5):491-494. doi: 10.1002/jmv.25709. Epub 2020 Feb 21.
5
Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 Infection.SARS-CoV、MERS-CoV 和 SARS-CoV-2 感染中的免疫致病反应和血液病理效应的重点。
Front Immunol. 2020 May 12;11:1022. doi: 10.3389/fimmu.2020.01022. eCollection 2020.
6
[Comparison of pathological changes and pathogenic mechanisms caused by H1N1 influenza virus, highly pathogenic H5N1 avian influenza virus, SARS-CoV, MERS-CoV and 2019-nCoV].甲型H1N1流感病毒、高致病性H5N1禽流感病毒、严重急性呼吸综合征冠状病毒、中东呼吸综合征冠状病毒及2019新型冠状病毒所致病理变化与致病机制比较
Zhonghua Bing Li Xue Za Zhi. 2020 May 8;49(5):511-516. doi: 10.3760/cma.j.cn112151-20200301-00155.
7
Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples.基于临床样本的 COVID-19 相关肺损伤的病理特征：初步蛋白质组学报告。
Signal Transduct Target Ther. 2020 Oct 15;5(1):240. doi: 10.1038/s41392-020-00355-9.
8
Atypical lymphocyte morphology in SARS-CoV-2 infection.新型冠状病毒肺炎感染中的非典型淋巴细胞形态
Pathol Res Pract. 2020 Sep;216(9):153063. doi: 10.1016/j.prp.2020.153063. Epub 2020 Jun 10.
9
Molecular Basis of Pathogenesis of Coronaviruses: A Comparative Genomics Approach to Planetary Health to Prevent Zoonotic Outbreaks in the 21st Century.冠状病毒发病机制的分子基础：以比较基因组学方法研究行星健康，以预防 21 世纪的人畜共患病爆发。
OMICS. 2020 Nov;24(11):634-644. doi: 10.1089/omi.2020.0131. Epub 2020 Sep 16.
10
Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions.在 COVID-19 中，单核细胞和巨噬细胞对局部组织炎症和细胞因子风暴的贡献：来自 SARS 和 MERS 的教训，以及潜在的治疗干预措施。
Life Sci. 2020 Sep 15;257:118102. doi: 10.1016/j.lfs.2020.118102. Epub 2020 Jul 18.
引用本文的文献
1
Gastroprotective, Antioxidant, Anti-Inflammatory, and Toxicological Evaluation of Stem Bark Extracts of and .[植物名称1]和[植物名称2]茎皮提取物的胃保护、抗氧化、抗炎及毒理学评价
Pharmaceuticals (Basel). 2025 Aug 11;18(8):1184. doi: 10.3390/ph18081184.
2
Do Long COVID and COVID Vaccine Side Effects Share Pathophysiological Picture and Biochemical Pathways?长期新冠症状和新冠疫苗副作用是否具有共同的病理生理特征和生化途径？
Int J Mol Sci. 2025 Aug 15;26(16):7879. doi: 10.3390/ijms26167879.
3
COVID-19: a vascular nightmare unfolding.新冠病毒肺炎：一场正在展现的血管噩梦。
Front Immunol. 2025 Aug 1;16:1593885. doi: 10.3389/fimmu.2025.1593885. eCollection 2025.
4
Twelve weeks of respiratory muscle training enhance respiratory function in CrossFit athletes returning to exercise post-SARS-CoV-2 infection: single-blind randomized clinical trial.为期十二周的呼吸肌训练可增强感染SARS-CoV-2后恢复运动的CrossFit运动员的呼吸功能：单盲随机临床试验。
BMC Sports Sci Med Rehabil. 2025 Aug 14;17(1):236. doi: 10.1186/s13102-025-01261-9.
5
Exploring pentoxifylline as an alternative treatment for dexamethasone in diabetic patients with COVID-19: a randomized controlled trial.探索己酮可可碱作为2型糖尿病合并COVID-19患者地塞米松替代治疗的疗效：一项随机对照试验。
Eur J Med Res. 2025 Jul 1;30(1):540. doi: 10.1186/s40001-025-02678-1.
6
Improvement on Ferrous Ion Accumulation and Mitochondrial Dysfunction in the COVID-19 Pseudovirus-Infected Cell Model Simulating the Long COVID Status by Nutritional Strategy.通过营养策略改善模拟新冠长期症状状态的新冠病毒假病毒感染细胞模型中的亚铁离子蓄积和线粒体功能障碍
Life (Basel). 2025 Jun 18;15(6):980. doi: 10.3390/life15060980.
7
A Plant-Based Dietary Supplement Exhibits Significant Effects on Markers of Oxidative Stress, Inflammation, and Immune Response in Subjects Recovering from Respiratory Viral Infection: A Randomized, Double-Blind Clinical Study Using Vitamin C as a Positive Control.一种植物性膳食补充剂对呼吸道病毒感染康复期受试者的氧化应激、炎症和免疫反应标志物具有显著影响：一项以维生素C作为阳性对照的随机双盲临床研究。
Int J Mol Sci. 2025 May 29;26(11):5209. doi: 10.3390/ijms26115209.
8
Advances in Molecular Research of Tracheobronchial Tree Aging: A Systematic Review.气管支气管树老化的分子研究进展：一项系统综述
Int J Mol Sci. 2025 May 27;26(11):5128. doi: 10.3390/ijms26115128.
9
Persistent Monocytic Bioenergetic Impairment and Mitochondrial DNA Damage in PASC Patients with Cardiovascular Complications.伴有心血管并发症的新冠后综合征（PASC）患者存在持续性单核细胞生物能量损伤和线粒体DNA损伤。
Int J Mol Sci. 2025 May 9;26(10):4562. doi: 10.3390/ijms26104562.
10
Sustainable Polyphenol-Rich Extracts from Agricultural By-Products: Infectivity Inhibition Potential for Human Coronavirus 229E.来自农业副产品的可持续富含多酚提取物：对人冠状病毒229E的感染性抑制潜力
Molecules. 2025 Apr 17;30(8):1806. doi: 10.3390/molecules30081806.
本文引用的文献
1
Covid-19: risk factors for severe disease and death.新冠病毒病：重症和死亡的风险因素
BMJ. 2020 Mar 26;368:m1198. doi: 10.1136/bmj.m1198.
2
Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients.老年 COVID-19 患者的临床特征：与中青年患者的比较。
J Infect. 2020 Jun;80(6):e14-e18. doi: 10.1016/j.jinf.2020.03.005. Epub 2020 Mar 27.
3
Covid-19 - Navigating the Uncharted.新冠疫情——探索未知领域。
N Engl J Med. 2020 Mar 26;382(13):1268-1269. doi: 10.1056/NEJMe2002387. Epub 2020 Feb 28.
4
Defining the Epidemiology of Covid-19 - Studies Needed.定义新冠病毒病的流行病学——所需的研究。
N Engl J Med. 2020 Mar 26;382(13):1194-1196. doi: 10.1056/NEJMp2002125. Epub 2020 Feb 19.
5
The reproductive number of COVID-19 is higher compared to SARS coronavirus.与严重急性呼吸综合征冠状病毒相比，新型冠状病毒肺炎的繁殖数更高。
J Travel Med. 2020 Mar 13;27(2). doi: 10.1093/jtm/taaa021.
6
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.中国武汉地区 2019 年新型冠状病毒感染患者的临床特征。
Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
7
Human Coronavirus: Host-Pathogen Interaction.人类冠状病毒：宿主-病原体相互作用。
Annu Rev Microbiol. 2019 Sep 8;73:529-557. doi: 10.1146/annurev-micro-020518-115759. Epub 2019 Jun 21.
8
Redox Biology of Respiratory Viral Infections.呼吸病毒感染的氧化还原生物学。
Viruses. 2018 Jul 26;10(8):392. doi: 10.3390/v10080392.
9
Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways.大黄酸通过调节氧化应激、TLR4、Akt、MAPK和NF-κB信号通路发挥抗甲型流感病毒活性。
PLoS One. 2018 Jan 31;13(1):e0191793. doi: 10.1371/journal.pone.0191793. eCollection 2018.
10
The Oxygen Paradox, oxidative stress, and ageing.氧悖论、氧化应激与衰老
Arch Biochem Biophys. 2016 Apr 1;595:28-32. doi: 10.1016/j.abb.2015.11.015.
Zotero 插件