有机荧光团包封于具有缓释功能的磷酸钙纳米颗粒中。
Entrapment of organic fluorophores in calcium phosphate nanoparticles with slow release.
作者信息
Sadallah Laila, Boukhris Aicha, Hannache Hassan, Gmouh Said
机构信息
Department of Chemistry, Faculty of Science Ben M'sik, Hassan II University of Casablanca, Casablanca Morocco.
Higher School of Textile and Clothing Industries, Casablanca Morocco.
出版信息
Turk J Chem. 2020 Feb 11;44(1):142-154. doi: 10.3906/kim-1902-57. eCollection 2020.
Two organic fluorophores, fluorescein (F) and rhodamine B (Rd), were entrapped in calcium phosphate nanoparticles. The as-obtained nanoparticles can be used for biological release applications. For this aim, calcium phosphate nanoparticles were synthesized using the precipitation method. Structural analysis of these nanoparticles was performed using XRD, FTIR, and Raman spectroscopy, confirming that the synthesized nanoparticles were hydroxyapatite. TEM and SEM analyses demonstrated that these nanoparticles had a size of 20 nm and a well-defined morphology. F and Rd (about 0.5 wt.%) were entrapped in these nanoparticles and their release, as a function of time, was studied via UV-Vis spectroscopy. The obtained results showed that the release of both fluorophores was progressive over time. The trapping efficiencies of the fluorophores were 67.15% and 90.76% for F and Rd, respectively.
两种有机荧光团，即荧光素（F）和罗丹明B（Rd），被包裹在磷酸钙纳米颗粒中。所制备的纳米颗粒可用于生物释放应用。为此，采用沉淀法合成了磷酸钙纳米颗粒。利用X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和拉曼光谱对这些纳米颗粒进行了结构分析，证实合成的纳米颗粒为羟基磷灰石。透射电子显微镜（TEM）和扫描电子显微镜（SEM）分析表明，这些纳米颗粒的尺寸为20纳米，形态明确。F和Rd（约0.5 wt.%）被包裹在这些纳米颗粒中，并通过紫外-可见光谱研究了它们随时间的释放情况。所得结果表明，两种荧光团的释放均随时间逐渐进行。F和Rd的荧光团捕获效率分别为67.15%和90.76%。
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