用苯甲酸钠处理的大鼠体内的线粒体尿素循环酶

Mitochondrial urea cycle enzymes in rats treated with sodium benzoate.

作者信息

Colombo J P, Bachmann C, Pfister U, Gradwohl M

机构信息

Department of Clinical Chemistry, Inselspital University of Berne, Switzerland.

出版信息

Biochem Biophys Res Commun. 1988 Mar 15;151(2):872-7. doi: 10.1016/s0006-291x(88)80362-0.

DOI:10.1016/s0006-291x(88)80362-0

PMID:3348818

Abstract

Since sodium benzoate, which is widely used to treat hyperammonemia its effect on mitochondrial urea cycle enzymes was investigated. its effect on mitochondrial urea cycle enzymes was investigated. Sodium benzoate was administered to urease treated hyperammonemic rats and controls. In both groups no interference with the activity of carbamylphosphate synthetase, ornithine carbamyltransferase and N-acetylglutamate synthetase in the liver could be observed at concentrations of benzoate in plasma found in hyperammonemic patients. Careful monitoring of plasma levels reduces benzoate toxicity as shown in a patient with argininosuccinic aciduria.

摘要

由于苯甲酸钠被广泛用于治疗高氨血症，因此研究了其对线粒体尿素循环酶的影响。对经脲酶处理的高氨血症大鼠和对照组给予苯甲酸钠。在高氨血症患者血浆中发现的苯甲酸盐浓度下，两组均未观察到对肝脏中氨甲酰磷酸合成酶、鸟氨酸氨甲酰转移酶和N-乙酰谷氨酸合成酶活性的干扰。如在一名精氨琥珀酸尿症患者中所示，仔细监测血浆水平可降低苯甲酸盐毒性。