Gomez M, Jordá A, Cabo J, Grisolía S
FEBS Lett. 1983 May 30;156(1):119-22. doi: 10.1016/0014-5793(83)80260-9.
Rats fasted for 3 and 6 days showed an increase in the activity, per g of liver but not per total liver, of the mitochondrial urea cycle enzymes, carbamylphosphate synthetase and ornithine transcarbamylase. The activity of N-acetylglutamate synthetase, both per g and per total liver, increased by the third day and then decreased on the sixth day of fasting. The cytosolic enzyme N-acetyldeacylase showed the same general pattern as the N-acetylglutamate synthetase except that the relative proportion of synthetase over deacylase was higher at the third day of starvation. The N-acetylglutamate level/g liver increases in relation to the number of days of fasting.
禁食3天和6天的大鼠，其肝脏线粒体尿素循环酶（氨甲酰磷酸合成酶和鸟氨酸转氨甲酰酶）的活性，以每克肝脏计算有所增加，但以整个肝脏计算则无增加。N-乙酰谷氨酸合成酶的活性，无论以每克肝脏还是整个肝脏计算，在禁食第三天增加，然后在禁食第六天下降。胞质酶N-乙酰脱酰酶呈现出与N-乙酰谷氨酸合成酶相同的总体模式，只是在饥饿第三天合成酶相对于脱酰酶的相对比例更高。每克肝脏的N-乙酰谷氨酸水平随禁食天数增加而升高。
