Saito Y, Bujo H, Morisaki N, Shirai K, Yoshida S
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.
Atherosclerosis. 1988 Feb;69(2-3):161-4. doi: 10.1016/0021-9150(88)90010-x.
Cultured intimal smooth muscle cells (SMC) were prepared from rabbits in which a cannula had been inserted into the abdominal aorta 4 weeks previously. The patterns of growth proliferative rates, and lipoprotein metabolism of cultures of intimal and medial SMC from intact aortic media were compared. Intimal SMC proliferated more rapidly than medial SMC. Both low density lipoprotein (LDL) and acetylated LDL bound to intimal SMC, whereas only LDL bound to medial SMC. These findings suggest a phenotypic difference between intimal and medial SMC.
培养的内膜平滑肌细胞（SMC）取自4周前已将套管插入腹主动脉的兔子。比较了来自完整主动脉中膜的内膜和中膜SMC培养物的生长增殖率模式和脂蛋白代谢情况。内膜SMC比中膜SMC增殖更快。低密度脂蛋白（LDL）和乙酰化LDL均与内膜SMC结合，而只有LDL与中膜SMC结合。这些发现表明内膜和中膜SMC之间存在表型差异。
