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二芳基链烷类化合物作为来自……茎部的强效酪氨酸酶抑制剂

Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of .

作者信息

Dang Phu H, Le Tho H, Do Truong N V, Nguyen Hai X, Nguyen Mai T T, Nguyen Nhan T

机构信息

Faculty of Chemistry, University of Science, 227 Nguyen Van Cu Street, Ward 4, District 5, Ho Chi Minh City, Vietnam.

Vietnam National University, Quarter 6, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam.

出版信息

Evid Based Complement Alternat Med. 2021 Jan 4;2021:8872920. doi: 10.1155/2021/8872920. eCollection 2021.

DOI:10.1155/2021/8872920
PMID:33488760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7801053/
Abstract

From a CHCl-soluble extract of the stems of (Anacardiaceae), two new diarylalkanoids, semedienone () and semetrienone (), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activity with the IC values of 0.033 and 0.11 M, respectively. Docking studies of and with -tyrosinase were carried out to analyze their interactions. Accordingly, semedienone () showed good interactions with the peroxide group and amino acid residues. The biosynthesis of the isolated diarylalkanoids was proposed.

摘要

从漆树科植物[具体植物名称未给出]茎的氯仿可溶提取物中，分离出两种新的二芳基烷烃类化合物，即半二烯酮（[化合物结构未给出]）和半三烯酮（[化合物结构未给出]）。基于核磁共振光谱数据解析阐明了它们的结构。这些化合物具有较强的酪氨酸酶抑制活性，IC50值分别为0.033和0.11 μM。对[两种化合物名称]与α - 酪氨酸酶进行对接研究以分析它们之间的相互作用。因此，半二烯酮（[化合物结构未给出]）与过氧化物基团和氨基酸残基表现出良好的相互作用。还提出了分离得到的二芳基烷烃类化合物的生物合成途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d0/7801053/42933dfa4618/ECAM2021-8872920.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d0/7801053/600baa4e65f3/ECAM2021-8872920.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d0/7801053/19da45991dc2/ECAM2021-8872920.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d0/7801053/5089ce29a758/ECAM2021-8872920.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d0/7801053/42933dfa4618/ECAM2021-8872920.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d0/7801053/600baa4e65f3/ECAM2021-8872920.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d0/7801053/19da45991dc2/ECAM2021-8872920.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d0/7801053/5089ce29a758/ECAM2021-8872920.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d0/7801053/42933dfa4618/ECAM2021-8872920.004.jpg

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