Nguyen Nhan T, Dang Phu H, Nguyen Hai X, Do Truong N V, Le Tho H, Le Tuyen Q H, Nguyen Mai T T
Faculty of Chemistry, University of Science, 227 Nguyen Van Cu Street, Ward 4, District 5, Ho Chi Minh City, Vietnam.
Vietnam National University, Quarter 6, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam.
Evid Based Complement Alternat Med. 2021 Jul 1;2021:5561176. doi: 10.1155/2021/5561176. eCollection 2021.
Two new stilbene derivatives, named strebluses C and D, were isolated from the EtOAc-soluble fraction of the stems of (Moraceae). Its absolute configuration was elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. Streblus C possesses strong tyrosinase inhibitory activity with an IC value of 0.01 M. Docking studies of and with -tyrosinase were carried out to analyze their interactions. The analysis of the docked poses confirmed that showed better binding affinity for -tyrosinase than that of .
从桑科植物茎的乙酸乙酯可溶部分中分离出两种新的芪衍生物，命名为strebluses C和D。基于核磁共振光谱数据解释和旋光计算确定了其绝对构型。Streblus C具有很强的酪氨酸酶抑制活性，IC值为0.01 M。对streblus C和D与α-酪氨酸酶进行对接研究以分析它们之间的相互作用。对接构象分析证实，streblus C对α-酪氨酸酶的结合亲和力优于streblus D。
