Mao Weipu, Wu Jianping, Wang Keyi, Xu Bin, Chen Ming
Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Ther Adv Urol. 2020 Dec 23;12:1756287220981510. doi: 10.1177/1756287220981510. eCollection 2020 Jan-Dec.
The purpose of this study was to investigate the relationship between marital status and the prognosis of patients with upper tract urothelial carcinoma (UTUC) treated with nephroureterectomy (NU).
Patients with UTUC who received NU treatment were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015. Kaplan-Meier curves and Cox regression were used to analyze the effect of marital status on cancer-specific survival (CSS), and 1:1 propensity score matching (PSM) was performed for married and unmarried patients to explore further the effect of marital status on patients with UTUC.
Among 1565 eligible patients, 960 (61.3%) were married and 605 (38.7%) were unmarried, of which 146 (9.3%) were divorced/separated, 306 (19.6%) were widowed, and 153 (9.8%) were single. Multivariate Cox regression analysis showed that marital status was not an independent risk factor for patients with UTUC treated with NU. After stratification by grade and SEER stage, multivariate analysis showed that there was no significant difference in 5-year CSS between divorced/separated, widowed, and single patients compared with married patients in different grades and SEER stages. In addition, after PSM analysis, marital status was still not an independent risk factor for patients with UTUC treated with NU.
For patients with UTUC treated with NU, marital status has no prognostic effect on CSS.
本研究旨在探讨婚姻状况与接受肾输尿管切除术（NU）治疗的上尿路尿路上皮癌（UTUC）患者预后之间的关系。
从2004年至2015年的监测、流行病学和最终结果（SEER）数据库中识别出接受NU治疗的UTUC患者。采用Kaplan-Meier曲线和Cox回归分析婚姻状况对癌症特异性生存（CSS）的影响，并对已婚和未婚患者进行1:1倾向评分匹配（PSM），以进一步探讨婚姻状况对UTUC患者的影响。
在1565例符合条件的患者中，960例（61.3%）已婚，605例（38.7%）未婚，其中146例（9.3%）离婚/分居，306例（19.6%）丧偶，153例（9.8%）单身。多因素Cox回归分析显示，婚姻状况不是接受NU治疗的UTUC患者的独立危险因素。按分级和SEER分期分层后，多因素分析显示，在不同分级和SEER分期中，离婚/分居、丧偶和单身患者与已婚患者的5年CSS无显著差异。此外，PSM分析后，婚姻状况仍然不是接受NU治疗的UTUC患者的独立危险因素。
对于接受NU治疗的UTUC患者，婚姻状况对CSS无预后影响。
