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天然淋巴细胞在特定疾病状态——癌症形成、代谢紊乱和炎症中的作用。

The role of innate lymphoid cells in selected disease states - cancer formation, metabolic disorder and inflammation.

作者信息

Poniewierska-Baran Agata, Tokarz-Deptuła Beata, Deptuła Wiesław

机构信息

Department of Immunology, Faculty of Biology, University of Szczecin, Szczecin, Poland.

Veterinary Center of the Nicolaus Copernicus University, Torun, Poland.

出版信息

Arch Med Sci. 2019 Nov 18;17(1):196-206. doi: 10.5114/aoms.2019.89835. eCollection 2021.

DOI:10.5114/aoms.2019.89835
PMID:33488872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7811321/
Abstract

Innate lymphoid cells (ILCs) are a recently described group of immune cells that can regulate homeostasis and protect mammalian organisms, including humans, from infections and diseases. Considering this, ILC research is still ongoing to better understand the biology of these cells and their roles in the human body. ILCs are a multifunctional group of immune cells, making it important for the medical community to be familiar with the latest research about the ILC families and their functions in selected disease states, such as cancer formation, metabolic disorders and inflammation. By discovering the roles of ILC populations and their participation in many disorders, we can improve disease diagnostics and patient healthcare.

摘要

固有淋巴细胞(ILCs)是最近被描述的一类免疫细胞,它们能够调节体内平衡,并保护包括人类在内的哺乳动物机体免受感染和疾病侵害。鉴于此,关于ILCs的研究仍在继续,以便更好地了解这些细胞的生物学特性及其在人体中的作用。ILCs是一类多功能免疫细胞,因此对于医学界来说,熟悉有关ILC家族及其在特定疾病状态(如癌症形成、代谢紊乱和炎症)中的功能的最新研究非常重要。通过发现ILC群体的作用及其在多种疾病中的参与情况,我们可以改善疾病诊断和患者医疗保健。

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本文引用的文献

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Innate IFN-γ-Producing Cells Developing in the Absence of IL-2 Receptor Common γ-Chain.在缺乏白细胞介素-2受体共同γ链的情况下发育的先天性产生干扰素-γ的细胞。
J Immunol. 2017 Aug 15;199(4):1429-1439. doi: 10.4049/jimmunol.1601701. Epub 2017 Jul 7.
2
The Role of Innate Lymphoid Cells in Immune-Mediated Liver Diseases.天然淋巴细胞在免疫介导性肝病中的作用。
Front Immunol. 2017 Jun 13;8:695. doi: 10.3389/fimmu.2017.00695. eCollection 2017.
3
Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets.主要转录因子之间的动态平衡决定了CD4 T细胞和固有淋巴细胞亚群的命运与功能。
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Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases.人类具有先天特征的NK样CD8(+) T细胞表型及其在癌症疾病中的相关性
Front Immunol. 2017 Mar 27;8:316. doi: 10.3389/fimmu.2017.00316. eCollection 2017.
5
ILC-poiesis: Making Tissue ILCs from Blood.ILC 发生:从血液中生成组织 ILC。
Immunity. 2017 Mar 21;46(3):344-346. doi: 10.1016/j.immuni.2017.03.002.
6
Killer ILCs in the Fat.脂肪中的杀伤性 ILCs。
Immunity. 2017 Feb 21;46(2):169-171. doi: 10.1016/j.immuni.2017.02.004.
7
Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency.人类固有淋巴细胞亚群在表型和频率上具有基于组织类型的异质性。
Immunity. 2017 Jan 17;46(1):148-161. doi: 10.1016/j.immuni.2016.11.005. Epub 2016 Dec 13.
8
Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance.脂肪组织驻留1型天然淋巴细胞促进肥胖相关的胰岛素抵抗。
Immunity. 2016 Aug 16;45(2):428-41. doi: 10.1016/j.immuni.2016.06.016. Epub 2016 Aug 2.
9
Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection.自然杀伤样 B 细胞对抗微生物感染的固有淋巴细胞的启动作用。
Immunity. 2016 Jul 19;45(1):131-44. doi: 10.1016/j.immuni.2016.06.019. Epub 2016 Jul 12.
10
The Yin and Yang of Innate Lymphoid Cells in Cancer.癌症中固有淋巴细胞的阴阳学说
Immunol Lett. 2016 Nov;179:29-35. doi: 10.1016/j.imlet.2016.06.003. Epub 2016 Jun 11.