Alsaif Manal A, Abdulbaqi Moshtag, Al Noaim Khalid, Aghbari Mustafa, Alabdulqader Muneera, Robinson Joan L
Department of Pediatrics, King, Abdulaziz Hospital, King Abdullah International Medical Research Center, Al-Ahsa, Saudi Arabia.
Department of Pediatrics, King Faisal University, College of Medicine, Al-Ahsa, Saudi Arabia.
Mediterr J Hematol Infect Dis. 2021 Jan 1;13(1):e2021002. doi: 10.4084/MJHID.2021.002. eCollection 2021.
The main aim was to report the prevalence and severity of serious bacterial infections (SBI) in children with sickle cell disease at King Abdulaziz Hospital (KAH), Al Ahsa, Saudi Arabia, to aid in determining whether outpatient management of such cases is appropriate.
We conducted a retrospective chart review of febrile children less than 14 years of age admitted with sickle cell disease 2005 through 2015.
During 320 admissions, 25 children had SBIs (8%) including pneumonia (n=11), osteomyelitis (n=8), bacteremia (n=3, all with species) and UTI (n=3). All recovered uneventfully.
It appears that in the current era, less than 10% of febrile children with sickle cell disease in our center are diagnosed with an SBI. Over 11 years, there were no sequelae or deaths from SBI. Given these excellent outcomes, outpatient ceftriaxone should be considered for febrile well-appearing children with sickle cell disease if they have no apparent source and parents are judged to be reliable.
主要目的是报告沙特阿拉伯艾哈萨国王阿卜杜勒阿齐兹医院（KAH）镰状细胞病患儿严重细菌感染（SBI）的患病率和严重程度，以协助确定对此类病例进行门诊管理是否合适。
我们对2005年至2015年因镰状细胞病入院的14岁以下发热儿童进行了回顾性病历审查。
在320例入院病例中，25名儿童患有SBI（8%），包括肺炎（n = 11）、骨髓炎（n = 8）、菌血症（n = 3，均为[具体菌种]）和尿路感染（n = 3）。所有患儿均顺利康复。
在当前时代，我们中心发热的镰状细胞病患儿中，不到10%被诊断为SBI。在11年期间，没有因SBI导致的后遗症或死亡。鉴于这些良好的结果，如果发热的镰状细胞病患儿看起来情况良好、没有明显感染源且家长被认为可靠，应考虑门诊使用头孢曲松治疗。
