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伴单克隆免疫球蛋白沉积的增殖性肾小球肾炎：对一种新的罕见疾病的成功治疗

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: Successful treatment for new and rare entity.

作者信息

Jerbi Mouna, El Fatmi Rym, Gaied Hanene, Belloumi Dorra, Torjemane Lamia, Aoudia Raja, Goucha Rim, Abdallah Taieb Ben, Othman Tarek Ben

机构信息

Department of Nephrology Mongi Slim Hospital La Marsa Tunisia.

Faculty of Medicine Tunis University of Tunis El Manar Tunis Tunisia.

出版信息

Clin Case Rep. 2020 Nov 11;9(1):80-85. doi: 10.1002/ccr3.3439. eCollection 2021 Jan.

DOI:10.1002/ccr3.3439
PMID:33489136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7813026/
Abstract

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits is a new disorder with undefined treatment modalities. We propose cyclophosphamide-bortezomib-dexamethasone and autologous stem cell transplantation as a therapeutic protocol.

摘要

伴有单克隆免疫球蛋白沉积的增殖性肾小球肾炎是一种治疗方式尚不明确的新疾病。我们提出采用环磷酰胺-硼替佐米-地塞米松及自体干细胞移植作为一种治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53d/7813026/451f27f8045a/CCR3-9-80-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53d/7813026/a9c67eec678f/CCR3-9-80-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53d/7813026/b71c4cffee85/CCR3-9-80-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53d/7813026/eb779641c44e/CCR3-9-80-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53d/7813026/087382c0acad/CCR3-9-80-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53d/7813026/451f27f8045a/CCR3-9-80-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53d/7813026/a9c67eec678f/CCR3-9-80-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53d/7813026/b71c4cffee85/CCR3-9-80-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53d/7813026/eb779641c44e/CCR3-9-80-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53d/7813026/087382c0acad/CCR3-9-80-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f53d/7813026/451f27f8045a/CCR3-9-80-g005.jpg

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本文引用的文献

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Renal pathologic spectrum and clinical outcome of monoclonal gammopathy of renal significance: A large retrospective case series study from a single institute in China.肾意义单克隆丙种球蛋白血症的肾脏病理谱和临床转归：来自中国单一机构的一项大型回顾性病例系列研究。
Nephrology (Carlton). 2020 Mar;25(3):202-211. doi: 10.1111/nep.13633. Epub 2019 Aug 1.
2
Long term outcomes in monoclonal gammopathy of renal significance.肾脏意义单克隆丙种球蛋白病的长期预后。
Br J Haematol. 2019 Sep;186(5):706-716. doi: 10.1111/bjh.15987. Epub 2019 May 29.
3
Bortezomib Maintenance for the Treatment of Monoclonal Gammopathy of Renal Significance.
硼替佐米维持治疗具有肾脏意义的单克隆丙种球蛋白病
Mediterr J Hematol Infect Dis. 2019 Jan 1;11(1):e2019007. doi: 10.4084/MJHID.2019.007. eCollection 2019.
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A clone-directed approach may improve diagnosis and treatment of proliferative glomerulonephritis with monoclonal immunoglobulin deposits.克隆定向方法可能改善单克隆免疫球蛋白沉积性增生性肾小球肾炎的诊断和治疗。
Kidney Int. 2018 Jul;94(1):199-205. doi: 10.1016/j.kint.2018.02.020. Epub 2018 May 11.
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Monoclonal gammopathies of renal significance.具有肾脏意义的单克隆丙种球蛋白病
Nefrologia. 2017 Sep-Oct;37(5):465-477. doi: 10.1016/j.nefro.2017.03.012.
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[Classification and therapeutic management of monoclonal gammopathies of renal significance].[具有肾意义的单克隆丙种球蛋白病的分类与治疗管理]
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