循环白细胞介素-6（而非其他免疫介质）与高龄老年人的弗里德虚弱标准相关。
Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried's Frailty among Very Old Adults.
作者信息
Santos Morais Junior Gilberto, Ignacio Valenzuela Perez Diego, Cecília Tonet-Furioso Audrey, Gomes Lucy, Coelho Vilaça Karla Helena, Paulo Alves Vicente, Franco Moraes Clayton, Toledo Nóbrega Otávio
机构信息
Health Faculty, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília, DF, Brazil.
Kinesiology School and Physical Activity and Sports Science Master Program, Universidad Santo Tomás, Puerto Montt, Chile.
出版信息
J Aging Res. 2020 Nov 4;2020:6831791. doi: 10.1155/2020/6831791. eCollection 2020.
METHODS
One hundred and sixty-one very old patients (aged ≥80 years) devoid of cognitive decline were eligible for analyses. Clinical and biochemical data along with physical and cognitive assessments encompassing dual-energy X-ray scans and hand dynamometry were adopted to investigate frailty criteria, while circulating immune mediators ( and ) were assessed using high-throughput flow cytometry.
RESULTS
Preliminarily, correlated positively with waist-to-hip ratio and C-reactive protein and negatively with glycemia. In analyses controlled for these factors, serum levels of IL-6 were comparatively augmented among the very old participants with reduced grip strength (OR = 3.299; 95% CI 1.08-6.09; =0.032) and among those with slow walk speed (OR = 2.460; 95% CI 1.16-7.05; =0.022).
CONCLUSIONS
Our study shows a strong negative correlation of levels with Fried's frailty components of grip strength and walk speed in very old adults, regardless of confounding factors.
方法
161名无认知功能减退的高龄患者（年龄≥80岁）符合分析条件。采用临床和生化数据以及包括双能X线扫描和握力测量在内的身体和认知评估来研究衰弱标准，同时使用高通量流式细胞术评估循环免疫介质（和）。
结果
初步研究发现，与腰臀比和C反应蛋白呈正相关，与血糖呈负相关。在对这些因素进行控制的分析中，握力降低的高龄参与者（OR = 3.299；95% CI 1.08 - 6.09；P = 0.032）以及步行速度较慢的参与者（OR = 2.460；95% CI 1.16 - 7.05；P = 0.022）的血清白细胞介素-6水平相对升高。
结论
我们的研究表明，在高龄成年人中，无论存在混杂因素如何，白细胞介素-6水平与弗里德衰弱标准中的握力和步行速度成分呈强烈负相关。
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