Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, United States; Dipartimento Interdisciplinare di Medicina, Clinica Medica Cesare Frugoni, University of Bari Aldo Moro, Bari, Italy.
Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, United States.
Arch Gerontol Geriatr. 2020 Sep-Oct;90:104131. doi: 10.1016/j.archger.2020.104131. Epub 2020 May 30.
Previous studies have found an inverse relation between serum concentrations of interleukin (IL)-6 and physical performance in seniors, however this was limited to higher functioning older adults with low to moderate levels of inflammation. We explored the consistency of this association in a cohort of mobility limited older adults with chronic low-grade inflammation. This study included 289 participants (≥ 70 years old) with IL-6 level between 2.5 and 30 pg/mL and a walking speed < 1.0 m/sec from the ENRGISE Pilot study. Physical performance was assessed using the short physical performance battery (SPPB), usual gait speed over 400 m, grip strength, and knee extensor and flexor strength measured by isokinetic dynamometry at 60 and 180°/sec. There was a significant inverse correlation between log IL-6 and knee extensor strength at 60°/sec (r= -0.20, p = 0.002), at 180°/sec (r = -0.14, p = 0.037), and knee flexor strength at 60°/sec (r = -0.15, p = 0.021). After adjustment for potential confounders, the values of knee extensor strength at 60°/sec showed a trend toward a progressive reduction across IL-6 tertiles as IL-6 levels increased (p = 0.024). No significant association was found between IL-6 and other objectively measured physical performance. The findings were generally of smaller magnitude and less consistent than previously reported, which suggests that the associations are attenuated in those with both elevated inflammation and mobility limitations. These results have implications for planning and interpreting future intervention studies in older adults with low-grade inflammation and mobility limitations.
先前的研究发现，老年人血清白细胞介素（IL）-6 浓度与身体机能呈负相关，但这仅限于炎症程度较低且功能较高的老年人。我们在患有慢性低度炎症且行动受限的老年人队列中探索了这种关联的一致性。这项研究包括 289 名参与者（年龄≥70 岁），其 IL-6 水平在 2.5 到 30pg/mL 之间，行走速度<1.0m/sec，来自 ENRGISE 试点研究。使用短体适能测试（SPPB）评估身体机能，400m 常用行走速度，握力，以及通过等速测力计在 60°/sec 和 180°/sec 测量的膝关节伸肌和屈肌力量。IL-6 的对数与膝关节伸肌在 60°/sec（r=-0.20，p=0.002）、180°/sec（r=-0.14，p=0.037）和膝关节屈肌在 60°/sec（r=-0.15，p=0.021）的力量呈显著负相关。在调整潜在混杂因素后，随着 IL-6 水平的升高，膝关节伸肌在 60°/sec 的力量值呈逐渐降低的趋势，呈 IL-6 三分位趋势（p=0.024）。IL-6 与其他客观测量的身体机能之间没有显著关联。这些发现的幅度通常较小，且不如先前报道的那样一致，这表明在炎症程度升高且行动受限的人群中，关联减弱。这些结果对规划和解释患有低度炎症和行动受限的老年人的未来干预研究具有启示意义。
