巨大腹膜癌肉瘤合并微小高级别输卵管浆液性癌：一例报告
Bulky peritoneal carcinosarcoma with tiny high-grade serous carcinoma of the fallopian tube: a case report.
作者信息
Nakashima Ayaka, Maruyama Yasuyo, Saji Haruya, Hirabuki Tomoo, Mitomi Hiroyuki
机构信息
Department of Obstetrics and Gynecology, Odawara Municipal Hospital, 46 Kuno, Odawara, Kanagawa 250-8558 Japan.
Department of Obstetrics and Gynecology, Fujisawa Municipal Hospital, 2-6-1 Fujisawa, Fujisawa, Kanagawa 251-8550 Japan.
出版信息
Int Cancer Conf J. 2020 Oct 19;10(1):72-77. doi: 10.1007/s13691-020-00451-1. eCollection 2021 Jan.
Peritoneal carcinosarcoma is a highly aggressive and uncommon neoplasm that has carcinomatous and sarcomatous components; the malignancy rarely localizes to the omentum. We report a case of a bulky peritoneal carcinosarcoma with tiny high-grade serous carcinoma of the fallopian tube. A 60-year-old female with a huge pelvic mass (12 cm in diameter) underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and omentectomy for tumor debulking. Pathological findings showed minimally invasive high-grade serous carcinoma of the left fallopian tube and carcinosarcoma of the omentum. Similar p53 diffuse immunostaining in the omental carcinosarcoma and the tubal carcinoma provides evidence for a clonal relationship between the two neoplasias. This case suggests a small serous carcinoma, originating in the tubal mucosa, subsequently became implanted in the omentum and grew preferentially, converting to a carcinosarcoma at a remote site.
腹膜癌肉瘤是一种侵袭性很强且罕见的肿瘤，具有癌性和肉瘤性成分；这种恶性肿瘤很少局限于大网膜。我们报告一例巨大的腹膜癌肉瘤合并微小的高级别输卵管浆液性癌病例。一名60岁女性，盆腔有巨大肿块（直径12厘米），接受了全腹子宫切除术、双侧输卵管卵巢切除术和大网膜切除术以减瘤。病理结果显示左侧输卵管为微浸润高级别浆液性癌，大网膜为癌肉瘤。大网膜癌肉瘤和输卵管癌中相似的p53弥漫性免疫染色为这两种肿瘤之间的克隆关系提供了证据。该病例提示起源于输卵管黏膜的小浆液性癌随后种植于大网膜并优先生长，在远处部位转变为癌肉瘤。
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