Zhang Junyan, Zhu Zhi, Miao Zhifeng, Huang Xuanzhang, Sun Zhe, Xu Huimian, Wang Zhenning
Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, China.
Front Oncol. 2021 Jan 8;10:559230. doi: 10.3389/fonc.2020.559230. eCollection 2020.
Regenerating islet-derived type 4 (), a member of the calcium-dependent lectin gene superfamily, is abnormally expressed in various cancers, such as colorectal, gastric, gallbladder, pancreatic, ovarian, prostate, and lung cancer. is associated with a relatively unfavorable prognosis and clinicopathologic features in cancers, including advanced tumor and nodal stage, histological differentiation, and liver and peritoneal metastasis. Moreover, -positive cancer cells show more frequent resistance to chemoradiotherapy, especially 5-FU-based chemotherapy. participates in many aspects of carcinogenesis, including cell proliferation, apoptosis, cell cycle, invasion, metastasis, and drug resistance. The underlying mechanisms are complex and involve a series of signaling mediators and multiple pathways. Thus, may be a potential diagnostic and prognostic biomarker as well as a candidate therapeutic target in cancer patients. In this review, we systematically summarize the advances about the clinical significance, biological functions, and mechanisms underlying in cancer to provide new directions for future cancer research.
再生胰岛衍生因子4（Regenerating islet-derived type 4，Reg4）是钙依赖性凝集素基因超家族的成员之一，在多种癌症中异常表达，如结直肠癌、胃癌、胆囊癌、胰腺癌、卵巢癌、前列腺癌和肺癌。Reg4与癌症中相对不良的预后和临床病理特征相关，包括肿瘤晚期和淋巴结分期、组织学分化以及肝转移和腹膜转移。此外，Reg4阳性癌细胞对放化疗，尤其是基于5-氟尿嘧啶的化疗，表现出更频繁的耐药性。Reg4参与肿瘤发生的多个方面，包括细胞增殖、凋亡、细胞周期、侵袭、转移和耐药性。其潜在机制复杂，涉及一系列信号介质和多种途径。因此，Reg4可能是癌症患者潜在的诊断和预后生物标志物以及候选治疗靶点。在本综述中，我们系统地总结了Reg4在癌症中的临床意义、生物学功能和潜在机制的研究进展，为未来的癌症研究提供新的方向。
