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当抗生素专家对抗生素说“不”时。

When antibiotics experts say no to antibiotics.

作者信息

Thabit Abrar K, Turkistani Shouq A, Alsubaie Shahad A, Takroni Enas A, Basaeed Lamis F, Saadawi Daleen W

机构信息

PharmD, BCPS, Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, 7027 Abdullah Al-Sulaiman Road, Jeddah 22254-2265, Saudi Arabia.

PharmD, Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, 7027 Abdullah Al-Sulaiman Road, Jeddah 22254-2265, Saudi Arabia.

出版信息

Germs. 2020 Dec 28;10(4):380-384. doi: 10.18683/germs.2020.1230. eCollection 2020 Dec.

Abstract

Overuse or misuse of antibiotics is one reason for the emergence of antibiotic resistance. Here, we present four cases where antibiotics were started (or proposed) although they were not needed. The first case was asymptomatic bacteriuria where antibiotic therapy was initiated but then stopped after the case was referred to the infectious diseases (ID) service. The second case was a cholangiocarcinoma patient in whom four antibiotics were continued after completing the treatment for a remote infection. Hence, the ID team discontinued the unneeded therapy after considering that the inflammatory process was due to malignancy. The third case was a patient who was diagnosed with pneumonia in whom both antibiotics and an antiviral were initiated. However, antibiotic therapy was continued despite the lack of bacterial growth in the respiratory culture. Thus, it wasn't until the ID team evaluated the case and decided that the pneumonia was viral in nature that antibiotic therapy was discontinued. The last case was for a patient who presented with dry cough presumed to be a pneumonia and was about to be started on antibiotics. The ID team noticed the patient had a history of decompensated congestive heart failure causing the cough. Antibiotics were not initiated when lack of clinical findings suggestive of pneumonia was also confirmed. These cases represent an example of daily occurrences of antibiotics overuse. Healthcare providers are encouraged to augment their knowledge regarding the safe and judicious use of antibiotics, as well as consulting an ID expert if doubts concerning the necessity of antibiotics arise.

摘要

抗生素的过度使用或滥用是抗生素耐药性出现的一个原因。在此,我们呈现四个病例,在这些病例中,抗生素被启用(或被建议使用),尽管其实并无必要。第一个病例是无症状菌尿症,启动了抗生素治疗,但在该病例转诊至传染病科后治疗被停止。第二个病例是一名胆管癌患者,在完成对既往感染的治疗后仍继续使用四种抗生素。因此,传染病团队在考虑到炎症过程是由恶性肿瘤引起后,停用了不必要的治疗。第三个病例是一名被诊断为肺炎的患者,同时启用了抗生素和抗病毒药物。然而,尽管呼吸道培养未发现细菌生长,抗生素治疗仍继续进行。因此,直到传染病团队评估该病例并确定肺炎本质上是病毒性的,抗生素治疗才被停止。最后一个病例是一名出现干咳、疑似肺炎且即将开始使用抗生素的患者。传染病团队注意到该患者有失代偿性充血性心力衰竭病史,导致咳嗽。在确认缺乏提示肺炎的临床发现后,未启用抗生素。这些病例代表了抗生素过度使用的日常实例。鼓励医疗保健提供者增加他们关于安全、合理使用抗生素的知识,以及在对是否有必要使用抗生素存疑时咨询传染病专家。

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