Ma Qianli, He Jie
Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Ann Transl Med. 2020 Dec;8(24):1658. doi: 10.21037/atm-20-7424.
Lung adenocarcinoma (LUAD) is the most frequently diagnosed type of lung cancer with high percentage of tumor relapse and metastasis. The correlation between queuine tRNA-ribosyltransferase 1 () expression and LUAD remains largely unknown. In this study, we aim to investigate the potential role of expression in the prognosis of LUAD.
We abstracted data from The Cancer Genome Atlas (TCGA) and four independent Gene Expression Omnibus (GEO) datasets. In total, 1,012 LUAD samples and 112 normal tissue samples were selected. The relationship between expression, methylation, and clinical features in LUAD were determined, and bioinformatics analyses were also performed.
The expression of was higher in LUAD patients. A marked downregulation in methylation in LUAD was also found. Low expression was associated with longer overall survival across the GEO and TCGA datasets (P=0.0033, 0.0022, respectively). Furthermore, expression was significantly correlated with 'axoneme assembly', 'androgen response', and 'epithelial mesenchymal transition', as determined by Gene Set Enrichment Analysis (GSEA) and Gene Ontology (GO) term enrichment analysis.
was highly expressed in LUAD, and enhanced expression of might therefore serve as a biomarker for poor prognosis in LUAD. The result of bioinformatic analyses might present a new insight for investigating the pathogenesis of LUAD.
肺腺癌（LUAD）是最常被诊断出的肺癌类型，肿瘤复发和转移率高。喹啉tRNA-核糖基转移酶1（）的表达与肺腺癌之间的相关性在很大程度上仍不清楚。在本研究中，我们旨在探讨该表达在肺腺癌预后中的潜在作用。
我们从癌症基因组图谱（TCGA）和四个独立的基因表达综合数据库（GEO）中提取数据。总共选择了1012例肺腺癌样本和112例正常组织样本。确定了肺腺癌中该表达、甲基化与临床特征之间的关系，并进行了生物信息学分析。
肺腺癌患者中该的表达较高。还发现肺腺癌中该甲基化明显下调。在GEO和TCGA数据集中，低该表达与更长的总生存期相关（分别为P = 0.0033和0.0022）。此外，通过基因集富集分析（GSEA）和基因本体（GO）术语富集分析确定，该表达与“轴丝组装”、“雄激素反应”和“上皮间质转化”显著相关。
该在肺腺癌中高表达，因此该表达增强可能作为肺腺癌预后不良的生物标志物。生物信息学分析结果可能为研究肺腺癌的发病机制提供新的见解。
