Enhanced expression of queuine tRNA-ribosyltransferase 1 () predicts poor prognosis in lung adenocarcinoma.

BACKGROUND

Lung adenocarcinoma (LUAD) is the most frequently diagnosed type of lung cancer with high percentage of tumor relapse and metastasis. The correlation between queuine tRNA-ribosyltransferase 1 () expression and LUAD remains largely unknown. In this study, we aim to investigate the potential role of expression in the prognosis of LUAD.

METHODS

We abstracted data from The Cancer Genome Atlas (TCGA) and four independent Gene Expression Omnibus (GEO) datasets. In total, 1,012 LUAD samples and 112 normal tissue samples were selected. The relationship between expression, methylation, and clinical features in LUAD were determined, and bioinformatics analyses were also performed.

RESULTS

The expression of was higher in LUAD patients. A marked downregulation in methylation in LUAD was also found. Low expression was associated with longer overall survival across the GEO and TCGA datasets (P=0.0033, 0.0022, respectively). Furthermore, expression was significantly correlated with 'axoneme assembly', 'androgen response', and 'epithelial mesenchymal transition', as determined by Gene Set Enrichment Analysis (GSEA) and Gene Ontology (GO) term enrichment analysis.

CONCLUSIONS

was highly expressed in LUAD, and enhanced expression of might therefore serve as a biomarker for poor prognosis in LUAD. The result of bioinformatic analyses might present a new insight for investigating the pathogenesis of LUAD.