Bian Meng, Huang Shiqiong, Yu Dongsheng, Zhou Zheng
Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Pharmacy, The First Hospital of Changsha, Changsha, China.
Front Mol Biosci. 2021 Sep 30;8:659388. doi: 10.3389/fmolb.2021.659388. eCollection 2021.
Lung cancer, one of the most malignant tumors, has extremely high morbidity and mortality, posing a serious threat to global health. It is an urgent need to fully understand the pathogenesis of lung cancer and provide new ideas for its treatment. Interestingly, accumulating evidence has identified that transfer RNAs (tRNAs) and tRNA metabolism-associated enzymes not only participate in the protein translation but also play an important role in the occurrence and development of lung cancer. In this review, we summarize the different aspects of tRNA metabolism in lung cancer, such as tRNA transcription and mutation, tRNA molecules and derivatives, tRNA-modifying enzymes, and aminoacyl-tRNA synthetases (ARSs), aiming at a better understanding of the pathogenesis of lung cancer and providing new therapeutic strategies for it.
肺癌是最恶性的肿瘤之一，发病率和死亡率极高，对全球健康构成严重威胁。全面了解肺癌的发病机制并为其治疗提供新思路迫在眉睫。有趣的是，越来越多的证据表明，转运核糖核酸（tRNA）和tRNA代谢相关酶不仅参与蛋白质翻译，而且在肺癌的发生和发展中也发挥着重要作用。在本综述中，我们总结了肺癌中tRNA代谢的不同方面，如tRNA转录和突变、tRNA分子及其衍生物、tRNA修饰酶和氨酰-tRNA合成酶（ARS），旨在更好地理解肺癌的发病机制并为其提供新的治疗策略。
