Increased Expression of in Lung Adenocarcinoma Predicts Poor Prognosis: A Bioinformatics Analysis Based on TCGA Data.

Available evidence indicates that kinetochore-localized astrin/SPAG5-binding protein () is an oncogene in skin carcinoma. This study aimed to evaluate the prognostic value of in lung adenocarcinoma (LUAD) underlying the Cancer Genome Atlas (TCGA) database. The relationship between clinicopathological features and was analyzed with the Wilcoxon signed-rank test and logistic regression. The clinicopathological characteristics associated with overall survival (OS) were evaluated using Cox regression and the Kaplan-Meier method. Gene ontology (GO) analysis, gene set enrichment analysis (GSEA), and single-sample GSEA (ssGSEA) were performed using TCGA data. The expression level was found to be significantly higher in LUAD tissue than in normal lung tissue. Also, it correlated significantly with advanced clinicopathological characteristics. The Kaplan-Meier survival curve revealed a significant relationship of high expression of with poor OS in patients with LUAD. The multivariate Cox regression hazard model demonstrated the expression level as an independent prognostic factor for patients with LUAD. GO and GSEA analyses indicated the involvement of in cell cycle checkpoints, DNA replication, and G2-M checkpoint M phase. Based on ssGSEA analysis, had a positive relationship with Th2 cells and CD56 natural killer cells. The expression levels in several types of immune cells were significantly different. The findings suggested that the increased expression level of was significantly associated with the progression of LUAD and could also serve as a novel prognostic biomarker for patients with LUAD.